Agonists Flashcards
0
Q
Bethanechol
A
- direct acting cholinergic agonist
- indicated in atonic bladder (postpartum, surgery)
- contraindicated with physical obstruction, asthma, peptic ulcers
- adverse effects: sweating, salivation, flushing, decreased BP, nausea, abdominal pain, diarrhea, bronchospasm
1
Q
Acetylcholine
A
-direct acting cholinergic agonist, not used therapeutically
2
Q
Carbachol
A
- direct acting cholinergic agonist
- used topically as a miotic to decrease IOP (GLAUCOMA)
- can stimulate M and N receptors
3
Q
Pilocarpine
A
- direct acting cholinergic agonist
- DOC for emergency lowering of both wide and narrow angle GLAUCOMA, treat xerostomia (dry mouth)
- adverse effects: CNS disturbances, miosis
4
Q
Edrophonium
A
- Reversible indirect cholinergic agonist
- diagnosis of myasthenia gravis
5
Q
Physostigmine
A
- Reversible indirect acting cholinergic agonist
- indicated in atony (GI and bladder), treatment for ANTICHOLINERGIC OD, GLAUCOMA
- can enter CNS and may cause convulsions, vomiting, salivation, bradycardia, respiratory arrest, miosis, irritation
6
Q
Neostigmine
A
- Reversible indirect acting cholinergic agonist
- treatment for myasthenia gravis, NM BLOCKER OD
- adverse effects: salivation, flushing, decreased BP, diarrhea
7
Q
Pyridostigmine
A
- Reversible indirect acting cholinergic agonist
- treatment of myasthenia gravis (longer duration and fewer side effects than neostigmine)
- NAPP: nerve agent ore treatment: protects from irreversible AChE inhibitors
8
Q
Toxins, poisons, nerve agents, insecticides
A
- irreversible indirect acting cholinergic agonist
- antidote: pralidoxime (reactivate AChE if used before aging) + atropine (for muscarinic effects)
9
Q
Echothiophate
A
- irreversible indirect acting cholinergic agonist
- GLAUCOMA
- actions: muscle paralysis, respiratory arrest, convulsions
10
Q
Tacrine
A
- reversible indirect acting cholinergic agonist
- used in the treatment of mild to moderate ALZHEIMER’S
11
Q
Donepezil
A
- reversible indirect acting cholinergic agonist
- used in the treatment of mild to moderate ALZHEIMER’S
12
Q
Galantamine
A
- reversible indirect acting cholinergic agonist
- used in the treatment of mild to moderate ALZHEIMER’S
13
Q
Rivastigmine
A
- reversible indirect acting cholinergic agonist
- used in the treatment of mild to moderate ALZHEIMER’S