Agonists Flashcards

0
Q

Bethanechol

A
  • direct acting cholinergic agonist
  • indicated in atonic bladder (postpartum, surgery)
  • contraindicated with physical obstruction, asthma, peptic ulcers
  • adverse effects: sweating, salivation, flushing, decreased BP, nausea, abdominal pain, diarrhea, bronchospasm
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1
Q

Acetylcholine

A

-direct acting cholinergic agonist, not used therapeutically

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2
Q

Carbachol

A
  • direct acting cholinergic agonist
  • used topically as a miotic to decrease IOP (GLAUCOMA)
  • can stimulate M and N receptors
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3
Q

Pilocarpine

A
  • direct acting cholinergic agonist
  • DOC for emergency lowering of both wide and narrow angle GLAUCOMA, treat xerostomia (dry mouth)
  • adverse effects: CNS disturbances, miosis
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4
Q

Edrophonium

A
  • Reversible indirect cholinergic agonist

- diagnosis of myasthenia gravis

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5
Q

Physostigmine

A
  • Reversible indirect acting cholinergic agonist
  • indicated in atony (GI and bladder), treatment for ANTICHOLINERGIC OD, GLAUCOMA
  • can enter CNS and may cause convulsions, vomiting, salivation, bradycardia, respiratory arrest, miosis, irritation
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6
Q

Neostigmine

A
  • Reversible indirect acting cholinergic agonist
  • treatment for myasthenia gravis, NM BLOCKER OD
  • adverse effects: salivation, flushing, decreased BP, diarrhea
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7
Q

Pyridostigmine

A
  • Reversible indirect acting cholinergic agonist
  • treatment of myasthenia gravis (longer duration and fewer side effects than neostigmine)
  • NAPP: nerve agent ore treatment: protects from irreversible AChE inhibitors
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8
Q

Toxins, poisons, nerve agents, insecticides

A
  • irreversible indirect acting cholinergic agonist

- antidote: pralidoxime (reactivate AChE if used before aging) + atropine (for muscarinic effects)

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9
Q

Echothiophate

A
  • irreversible indirect acting cholinergic agonist
  • GLAUCOMA
  • actions: muscle paralysis, respiratory arrest, convulsions
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10
Q

Tacrine

A
  • reversible indirect acting cholinergic agonist

- used in the treatment of mild to moderate ALZHEIMER’S

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11
Q

Donepezil

A
  • reversible indirect acting cholinergic agonist

- used in the treatment of mild to moderate ALZHEIMER’S

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12
Q

Galantamine

A
  • reversible indirect acting cholinergic agonist

- used in the treatment of mild to moderate ALZHEIMER’S

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13
Q

Rivastigmine

A
  • reversible indirect acting cholinergic agonist

- used in the treatment of mild to moderate ALZHEIMER’S

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