Agonist Vs. Antagonist Week 2 Flashcards
What is an Agonist?
Drugs that display a degree of affinity for a receptor and stimulate a response are considered agonists
What is a Full Agonist?
Maximal effect even when few receptors are activated
Examples of Full Agonists
Albuterol, Codeine, Fentanyl, Heroin, Hydrocodone, Hydromorphone, Levorphanol, Meperidine, Methadone, Morphine, Oxycodone, Oxymorphone
What is a Partial Agonist?
Submaximal effect even with all receptors activated
What is a Inverse Agonist?
Binds to the same receptors as another agonist but induces the opposite effect
What is an Antagonist?
Display an affinity and do not elicit a response
True or False: Antagonist have intrinsic activity
False. They do not
What can antagonist with high affinity do?
Antagonists with a high affinity for a receptor may be able to “bump” an agonist off the receptor and reverse the agonist activity.
What is a Non-competitive Antagonist?
Blocks at a separate site on the cell, and in turn changes the shape of the enzyme’s active site. — Binds to site other than receptor site, modifying receptor activity WITHOUT blocking the agonist site
What type of bond is used for a Non-Competitive Antagonist?
Covalent
What is a Competitive Agonist?
Binds to the receptor site and blocks activation, thus preventing binding of agonist
True or False: When a full agonist is present, the partial agonist can also act as a competitive antagonist
True
What is a Chemical Antagonist?
It is a type of antagonist that binds to a drug or ligand and renders it ineffective
How Does a Chemical Antagonist work?
Causes certain chemical changes in the ligand it binds. The antagonist binds to the agonist and forms an inactive complex that cannot perform any function.
True or False: A chemical antagonist binds to the receptor itself not the drug
False. It binds to the drug itself
