Aging Changes In The AC/vitreous/lacrimal System Flashcards
An acute rise in EVP results in a _____ ratio of increase IOP
1:1
Conventional pathway
- Cornrealscleral outflow
- TM and SC (main structures)
- IOP dependent
Unconventional pathway
- uveoscleral outflow
- ciliary muscle bundle
- IOP independent
Factors affecting IOP
Peak int he morning
Corneal thickness
Steroid
Outflow obstruction
Occlusive angle
-diabetes, uveitis, hyphema, pseudoexfoliation glaucoma, pigment dispersion glaucoma
Injury to the TM
-Fuchs heterochromic iritis, glaucomatocyclitic crisis
Classic Goldman equation
An acute ride in EVP results in a 1:1 ratio of increase in IOP
Aging changes in anterior chamber
- reduced anterior chamber depth, cortical cataract has more effect on this change
- reduced uveoscleral outflow. Increase in amount of connective tissue in ciliary muscle
- accumulation of extracellualr matrix plaque in TM
- increased outflow resistance in the TM and SC
Vitreous function
Support
Diffuse barrier
Metabolic barrier
Transparency
Vitreous function: support
PVD; macular edema
Vitreous function: metabolic buffer
Reduce neovascularixation in retina
- neovascular glaucoma
- NSC
Vitreous function: transparency
- synchisis scintillations
- asteroid hyalosis
Aging change of the vitreous
The gel structure becomes more liquefied with aging
Breakdown of the vitreous gel and aggregation of collagen fibrils due to increase of liquid potion
Vitreous syneresis
What is the most common cause of pVD
Vitreous syneresis
Floaters
Aggregation of collagen fibrils