Aging

Question 1

Aging

Answer 1

• Normal physiologic process - universal and inevitable
• time dependent loss of structure and function
• cellular and molecular level
• NOT DISEASE

Question 2

Theories of aging - Molecular

Answer 2

-Gene regulation theory

Question 3

Theories of aging - Cellular

Answer 3

• cell senescence
• telomeres
• reactive oxygen species

Question 4

Theories of aging - Systemic

Answer 4

• CONTROL AND MAINT (homeo) and communicate and adapt (stress, HPA)
• neuroendocrine
• immune

Question 5

Programmed Senescene theory

Answer 5

• Limits to the number of cell divisions that human cells can undergo
• Genetically programmed
  - with each cell division - small amount of DNA is lost at the end of each chromosome = role of telomeres
• Cell damage: reactive oxygen species

Question 6

Reactive oxygen species

Answer 6

DNA DAMAGE!

• free radicals (another name)
• damage occurs from the outside enviro (light, radiation, smoking, air pollution) but also inflammation and metabolism
• Damage dna and eventually kill the cell and eventually lead to aging

Question 7

Neuroendocrine theory

Answer 7

-HPA Axis is the master regulator and with aging it loses it’s effectiveness; gets worse over time with extra amounts of stress
-Aging is the “decreasing ability to survive stress”
Decrease ability in:
1. Coordinating communication
2. Programming physiological responses
3. Maintaining optimal functional state

Question 8

Telomeres

Answer 8

• On end of chromosomes, protective caps

- They don’t have any genetic material that is important j