Aggression & the Brain Flashcards

1
Q

Premeditated aggression

A

planned behavior with a clear goal in mind

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2
Q

Orbito-frontal PFC

A

-plays a role in regulation of aggressive behavior
-inverse relationship between orbito-frontal glucose
metabolism & history of aggression

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3
Q

Ventromedial prefrontal cortex is associated with..

A
  • Integration of cognition and affect

- anger suppression

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4
Q

Impulsive agression

A
  • provoked by strong emotions such as fear or anger

- allows us to defend ourselves in the faces of imminent threat

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5
Q

Phineas Gage

A
  • American railroad construction foreman with damage to most of his left frontal lobe due to a iron rode that went through his head.
  • Suffered personality changes
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6
Q

Hypothalamus (and agression)

A

High-frequency deep brain stimulation (DBS) found to decrease aggression, suggesting hypothalamus regulates aggression

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7
Q

Dorsolateral & dorsomedial PFC

A

Related to self-control & response to external

stimuli.

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8
Q

Reduced activity in the prefrontal cortex is associated with…

a) release of bottom-up control
b) release of top-down control
c) increase of bottom-up control
d) increase of top-down control

A

b) release of top-down control

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9
Q

Amygdala (and agression)

A
  • greater activity associated with impulsive aggression

- lower activity associated with premeditated aggression

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10
Q

TRUE OR FALSE

In normal development, our ability to suppress aggression increases and our aggressive tendencies decrease

A

TRUE

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11
Q

The limbic system includes: (3 main areas)

A
  • Amygdala
  • Hypothalamus
  • Cingulate cortex
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12
Q

TRUE OR FALSE

The serotonin and dopamine systems are functionally fully independent, so alterations in one do not affect the other.

A

False

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13
Q

Anterior cingulate cortex

A
  • Connections between ACC & amygdala (modulated by PFC) fundamental for anger control
  • Hypo-activity linked to aggression
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14
Q

What can the case of Phineas Gage tell us about aggression?

A

The frontal lobes cannot be the only brain area involved in aggression

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15
Q

TRUE OR FALSE

The serotonin system facilitates prefrontal function

A

TRUE

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16
Q

TRUE OR FALSE

Convicted murders or people with antisocial personality showed greater amygdala activation to aggressive scenarios

A

FALSE

Premeditated aggression shows less activation of the amygdala

17
Q

What are some treatments that can be used in extreme cases of aggression?

A
  • Serotonin re-uptake inhibitors (SSRIs)
  • Deep brain stimulation (DBS)
  • Dopamine antagonists
18
Q

mesocorticolimbic dopamine system

A
  • dopaminergic pathways from the VTA to the limbic system and cortex
  • involved in emotional response, cognitive control, reward & motivation
  • elevated DA system activity may enhance impulsive behavior
  • Haloperidol used to reduce aggressive outbursts in psychotic patients
19
Q

True or false

Serotonergic hypo-function may lead to dopaminergic hyper-function

A

True