Agents Targeting Nucleic acid synthesis

Question 1

Quinolones

Answer 1

Trimethoprim

Rifampicin

Metronidazole

Ciprofloxacin

Question 2

Ciprofloxacin

Answer 2

Quinolones

• Inhibit DNA gyrase
• Very active against Gram negs
• Also active against atypical pathogens
• Increasing resistance and risk of C. difficile

Question 3

Metronidazole

Answer 3

Nitroimidazole

It is effective for dracunculiasis, giardiasis, trichomoniasis, and amebiasis. It is the drug of choice for a first episode of mild-to-moderate Clostridium difficile colitis

Consuming alcohol while taking metronidazole has long been thought to have a disulfiram-like reaction

It inhibits nucleic acid synthesis by disrupting the DNA of microbial cells.

This function only occurs when metronidazole is partially reduced, and because this reduction usually happens only in anaerobic cells, it has relatively little effect upon human cells or aerobic bacteria