Agents of Yeast Infections Flashcards

1
Q

These are the three major of agents:

A

 Candida
 Cryptococcus
 Pneumocystis

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2
Q

It is considered as the fourth most common cause of blood borne infection in United States and accounting 10% - 15% of hospital-acquired septicemia cases.

A

Candida albicans

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3
Q

Yeast fungi can be classified into two groups:

A

Yeast

Yeastlike

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4
Q

Isolates that reproduce sexually, by forming either ascospores or basidiospores, are truly ___

A

yeasts

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5
Q

isolates that are not capable of sexual reproduction or whose sexual state has not yet been discovered

A

yeastlike fungi

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6
Q

Macroscopic characteristics:.
Color:
Texture:

A

 Color – white to cream or tan, with a few species forming pink- to salmon-colored colonies.
 Texture – mucoid (Cryptococcus spp.), butter-like, velvety to wrinkled

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7
Q

Some yeast isolates, referred to as _____ are darkly pigmented because of melanin in their cell walls

A

phaeoid yeasts,

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8
Q

 most notorious agents of yeast infection

 Clinical disease ranges from superficial skin infections to disseminated disease

A

Candida

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9
Q
  • the premier cause of yeast infection in the world.
  • recovered as normal biota from a variety of sites, including skin, the oral mucosa, the digestive tract, and the vagina.
A

C. albicans

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10
Q

One of the most widely recognized manifestations of C. albicans infection is _____ (oropharyngeal candidiasis), an infection of the oral mucosa and recognized as an indicator of immunosuppression.

A

thrush

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11
Q
  • common Candida species that causes disease and may account for 21% of all urinary yeast isolates.
  • Infections associated with this tend to be aggressive in patients with multiple comorbidities and may be difficult to treat with traditional antifungal therapy.
A

C. glabrata

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12
Q
  • multidrug-resistant yeast linked to high mortality rates associated with hospital-acquired infections worldwide.
  • likely transmitted from patient to patient in health care settings and has caused several outbreaks in
    numerous countries.
A

C. auris

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13
Q

Other notable species of Candida include______, _______

A

C. krusei and C. tropicalis.

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14
Q

It has become a major cause of outbreaks of nosocomial infections. These isolates are identified by the differences in their carbohydrate assimilation patterns and other secondary testing procedures.

A

C. parapsilosis

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15
Q

 important causes of meningitis, pulmonary disease, and septicemia

A

Cryptococcus

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16
Q

 it is the most notable pathogen in this Cryptococcus genus, is a major cause of opportunistic infection in patients with AIDS.

A

C. neoformans

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17
Q

 commonly found in soil contaminated with pigeon droppings and is most likely acquired by inhalation

A

Cryptococcus

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18
Q

 It is an emerging pathogen, particularly in the Pacific Northwest of the United States, similar to those caused by C. neoformans, targeting primarily immunocompromised patients. It an also cause disease in immunocompetent hosts

A

C. gattii

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19
Q

used primarily to examine cerebrospinal fluid for the presence of the encapsulated yeast Cryptococcus neoformans

A

India ink or nigrosine

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20
Q

 The use of India ink preparation is being replaced by use of _________because of the former’s low sensitivity and an easy-to-use lateral-flow assay, are recommended for routine use in clinical microbiology laboratories.

A

cryptococcal antigen tests

21
Q

 The cryptococcal antigen assays detect ___ and ____ in CSF and serum

A

C. neoformans and C. gattii

22
Q

are noted for producing blastoconidia only, without producing true hyphae or pseudohyphae on cornmeal agar

A

cryptococcus

23
Q

 All species of the Cryptococcus genus are urease ____, and the nitrate reaction differs

24
Q

 Production of _____ is a feature differentiating C. neoformans from many other Cryptococcus spp.

A

phenol oxidase

25
 A key laboratory characteristic is that C. gattii uses ___ as a sole carbon and nitrogen source in the presence of canavanine, whereas C. neoformans does not.
glycine
26
 ________ is commercially available and can be used to differentiate between C. neoformans and C. gattii.
Canavanine glycine bromothymol blue agar
27
 noted for their bright salmon pink color.  They resemble the cryptococci because they bear a capsule and are urease positive
Rhodotula
28
 They resemble the cryptococci because they bear a capsule and are urease positive. And some species are nitrate positive
Rhodotula
28
 They are not common agents of disease but have been known to cause opportunistic infections.
Rhodotula
29
 inhabit the lungs of many mammals
Pneumocystis
30
 _______was originally classified with the protozoa, but nucleic acid sequencing showed conclusively that the organism is a fungus.
Pneumocystis carinii
31
 _________is the species most commonly found in rats,
P. carinii
32
 is the species most often recovered from humans.
P. jirovecii
33
 acquired early in life; serologic studies have shown that most humans have antibodies or antigens by ____
2 to 4 years of age.
34
 it was initially identified as the causative agent in interstitial plasma cell pneumonia seen in malnourished or premature infants.
pneumocystis
35
 Since the early 1980s, it has remained one of the primary opportunistic infections found in patients with AIDS
pneumocystis
36
 Patients infected with ______ may have nonproductive cough, difficulty breathing, and a low-grade fever
Pneumocystis
37
nonfilamentous fungus.
pneumocystis
38
The life cycle (3) three stages:
 Trophozoite – 1 to 5 µm in size and is irregularly shaped  Pre-cyst – 5 to 8 µm  Cyst – thick-walled sphere of about 8 µm containing up to eight intracystic bodies.  MOT: respiratory route – cyst (infective stage)
39
The spores or _____ are released from the cyst in the lung, and these trophic forms multiply asexually by binary fission on the surface of the epithelial cells (pneumocyte) lining the lung.
intracystic bodies
40
Sexual reproduction by trophozoites also occurs, first producing a precyst and then the cyst containing spores or intracystic bodies.
True
41
Diagnosis was made by finding the cyst or trophozoite in tissue obtained through open lung biopsy. Specimens:
``` o bronchoalveolar lavage (BAL) fluid o transbronchial biopsy o tracheal aspirate o pleural fluid o induced sputum – least productive specimen ```
42
 Lavage and sputum specimens are often prepared using a _______
cytocentrifuge
43
 Histologic stains, such as ____ and ________
Giemsa and Gomori methenamine silver stains
44
 With the ______, the cyst wall stains black.
methenamine silver stain
45
often have a punched-out ping-pong ball appearance.
cyst
46
 With the _____, the organism appears round, and the cyst wall is barely visible.
Giemsa stain
47
 _____ can be used to screen specimens for Pneumocystis and other fungi. This stain detects any organism that contains chitin in its cell wall.
Calcofluor white
48
 Fungi, yeasts, and Pneumocystisspp. will fluoresce with a _______color when stained and viewed microscopically with ultraviolet light.
blue-white