Ageing Process Flashcards

1
Q

list cellular factors contributing to ageing

A

mutations in chromosomes and mitochondria
intracellular and extracellular aggregates
cellular loss
cellular senescence
extracellular protein cross links

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2
Q

what are telomeres and what happens to them during ageing

A

tips of chromosome, shorten throughout life due to cell division
leading to cell senescence

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3
Q

describe frailty

A

increased vulnerability to decompensation after a stressor event
loss of homeostasis and resilience

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4
Q

describe multimorbidity

A

having more than one chronic health condition increases risk of adverse events, poorer quality of life and hospital admission

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