Ageing Flashcards
1
Q
What is the definition of intrinsic ageing?
A
A time-dependent functional decline despite optimal conditions.
2
Q
What is the definition of frailty or ‘stressed ageing’?
A
Real-life loss of physiological reserve.
3
Q
What four point encompass ‘successful ageing’?
A
1) Personal growth
2) Increase in experiences or personal accomplishments
3) Wisdom
4) Perspective
4
Q
What happens to fibroblasts in culture after 50 doublings?
A
- Stop multiplying
- Have open nuclei
- Secrete inflammatory mediators
- Become enlarged
- Do not undergo apoptosis
5
Q
What do senescent cells not do?
A
Apoptose
6
Q
What are senolytics?
A
Drugs that induce apoptosis in senescent cells.
7
Q
What are two examples of senolytic drugs?
A
- Dasatinib
- Quercetin
8
Q
What is the demographic transition?
A
Transition from high fertility and high mortality to low fertility and low mortality.
