Ageing Flashcards

1
Q

Define ageing

A

Ageing is the process of growing older:

  • Biological
  • Psychological/cognitive
  • Social
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2
Q

Define life expectancy

A

Life expectancy is a statistical measure of how long a person can expect to live

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3
Q

What are the biological theories of ageing?

A
  1. Programmed ageing – the idea that ageing is genetically programmed to occur with time, and this process of deterioration eventually leads to death
  2. Damage or error theories – the idea that external or environmental forces gradually damage cells and organs, leading to ageing and death.
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4
Q

What are the theories explaining the programmed ageing theory?

A
  • Genetic life-span theory
  • Genetic predisposition theory
  • Telomere theory
  • Specific system theories (Neuroendocrine theory)
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5
Q

What are the theories explaining the damage/error theory of ageing?

A
  • Wear and tear theory
  • Rate of living theory
  • Waste product accumulation theory
  • Cross-linking theory
  • Free radical theory
  • Autoimmune theory
  • Error theories
  • Order to disorder theory
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6
Q

What challenges does society face as a result of population ageing?

A
  • Working life/retirement balance - not saving enough
  • Caring for older people, the sandwich generation
  • Extending healthy old age not just life expectancy
  • Inadequate or absent services - social care and housing
  • Outdated and ageist beliefs/assumptions
  • Medical system designed for single acute diseases
  • Limited accessibility for those with disabilities
  • loneliness and isolation
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7
Q

How does disease presentation change with age?

A
  • Frailty
  • Non-specific presentations
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8
Q

What are the difficulties with managing disease in older people?

A
  • Multimorbidity
  • Polypharmacy
  • Iatrogenic harm (caused by medical examination or treatment)
  • Comprehensive geriatric assessment
  • 5Rehabilitation
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9
Q

What is frailty?

A

A physiologic syndrome characterized by decreased reserve and resistance to stressors, resulting from cumulative decline across multiple physiologic systems, and causing vulnerability to adverse outcomes

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10
Q

How does frailty develop?

A
  1. Genetic and environmental factors
  2. Time
    • Cumulative molecular and cellular damage
  3. Reduced physiological reserve
  4. Physical activity and nutritional factors
  5. Frailty
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11
Q

What are the “geriatric syndromes”?

A

Non-specific presentations:

  • Falls
  • Delirium/confusion
  • Fluctuating disability
  • reduced mobility
  • Weight loss
  • Iatrogenic harm
  • “Not coping”
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12
Q

Why is frailty a problem?

A
  • Minor illnesses cause more pronounced changes in health
  • Increased hospital admissions
  • Increased duration of hospital stay
  • Increased care needs and dependence
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13
Q

Can frailty be treated?

A
  • Not really
  • Prevention rather than sure is best
  • Prevention through exercise, nutrition, lack of smoking and drinking is the best way
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14
Q

Using MI and PE as examples, what are the issues with the elderly’s non-specific presentation?

A
  • A wide variety of diseases can present as the same thing i.e. falls
  • Less likely to have the textbook symptoms e.g.
    • MI - less likely yo have chest pain
    • PE - less likely to have pleuritic chest pain or haemoptysis
  • More likely to have other symptoms
    • MI - more likely to be short of breath
    • PE - more likely to have syncope
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15
Q

Why is multimorbidity an issue?

A
  • Conditions impact on one another
  • Treatment for one condition may impact on another
  • Negative impacts
    • Worse QoL - more likely to be depressed
    • Increased functional impairment
    • Burden of treatment
    • Polypharmacy
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16
Q

Why is polypharmacy an issue?

A
  • Associated with bad outcomes:
    • Falls
    • Increased length of stay
    • Delirium
    • Mortality
  • Increased risk of adverse drug reactions
17
Q

Why are older people at increased risk of harm?

A
  • Reduced physiological reserve
  • Impaired compensation mechanisms
  • Comorbidities
  • Polypharmacy
  • Cognitive impairment
18
Q

How can outcomes be improved for people with frailty?

A
  • Comprehensive Geriatric Assessment (CGA)
    • A multidimensional, interdisciplinary assessment that leads to an individualised, goal based plan
19
Q

What are the benefits of CGA in the community and inpatients?

A

CGA in the community

  • Reduce admissions to institutional care
  • Reduce falls
  • Most benefit in mild or moderate frailty

CGA for frail inpatients

  • Reduces inpatient mortality
  • Reduces functional and cognitive decline
  • Reduces admission to institutional care
20
Q

What are the physical changes that occur in the brain with ageing?

A
  • Atrophy
  • Cerebrovascular disease - furring up of the small vessels in the brain
21
Q

What are the normal cognitive changes in older people?

A
  • Processing speed slows
  • Working memory slightly reduced
  • Simple attention ability preserved, but reduction in divided attention
  • Executive functions generally reduced
22
Q

What cognitive changes shouldn’t occur in normal people as they age?

A
  • No change in nondeclarative/implicit memory (memory that doesn’t take conscious effort to remember)
  • No change in visuospatial abilities
  • No overall change in language (some reduction in verbal fluency)
23
Q

What are the 2 components of higher brain function and which one does dementia effect?

A
  1. Level of consciousness - alertness
  2. Content of consciousness - cognition
  • Affected by dementia
24
Q

What are the features of dementia?

A
  • Progressive decline in all domains of cognition
  • Not just memory impairment
    • Loss of executive function
    • Functional impairment
    • Behavioural and psychological changes
    • Lack of insight
  • Impairment of function
  • Progressive
  • Degenerative
  • Irreversible
25
Q

What are the main types of dementia?

A

Alzheimer’s

Vascular

26
Q

What is delirium?

A
  • An acute, global failure of higher brain function
  • i.e. affecting level and content of consciousness
  • i.e. alertness and cognition
  • Acute Brain Failure = A medical emergency
27
Q

How do you distinguish between dementia and delirium?

A

Patient history vital

Dementia:

  • Chronic (months-years)
  • Gradual progression
  • No change in conscious level
  • Irreversible

Delirium:

  • Acute (hours-days)
  • Fluctuating
  • Main problem with alertness and attention
  • Usually reversible
  • Usually precipitated by something
28
Q

What are the screening tests for cognitive impairment?

A
  • 4AT score
  • MOCA
29
Q

What are the components of the 4AT score?

A
  1. Alertness
  2. AMT 4 (age, DOB, location, current year)
  3. Attention (months in backwards order)
  4. Acute changes/fluctuating course

Note:

The higher the score the more likely delirium

30
Q

What are the advantages of the MOCA score?

A
  • Covers a variety of domains of cognitive function
  • Brief to administer (10 mins)
  • Validated in a range of populations
  • Available in translated versions
  • Widely used
31
Q

What are the dis-advantages of the MOCA score?

A
  • Education level will affect results
  • Language level will affect results
  • Floor and ceiling effects
  • Can be poorly administered
  • Possibly practice/coaching effects