Affective disorders

Question 1

Biological pathway of depression

Answer 1

Mood

Question 2

Biological pathway of anxiety

Answer 2

Fear

Question 3

Animal models for depression

Answer 3

Forced swim test

Question 4

Example of animal model for anxiety

Answer 4

Fear conditioning

Question 5

What is the transmitter pathway and molecular target for depression?

Answer 5

Monoamines is the pathway with transmitter transporter as the molecular target

Question 6

what is the transmitter pathway and molecular target for anxiety?

Answer 6

transmitter pathway = GABA
molecular target = Inhibitory GABA receptor

Question 7

Problems facing clinical treatment of anxiety

Answer 7

withdrawal and addiction

Question 8

Panic disorders prevalence and symptoms?

Answer 8

4%, symptoms include panic attacks

Question 9

describe the monoaminehypothesis

Answer 9

elevates synaptic monoamines
1) blocks reuptake or inhibits catabolic break down by MAO increases
3) the amount of MA avaliable to activate
4) MA receptors
Thus hypothesis implies increased signalling

Question 10

Give some evidence fo the monoamine hypothesis

Answer 10

• tryptophan loading
• sensitivity to monoamines acts as an antidepressant
• measure levels of metabolites in CSF

Question 11

how does reserpine work?

Answer 11

antidepressant
Acts as a drug that depletes storage of monoamines, as prevents reuptake of the cytoplasmic transmitter into the vesicle

Question 12

Name two metabolites of 5-HT

Answer 12

• MHPG (3-methoxy-4-hydroxphenylglycol
• 5-hydroxy indoleacetic acid

Question 13

what specific monoamine receptor in post mortem tissue is altered

Answer 13

5-HT 2A