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GI-Week 6 > Aetiology & Pathophysiology of Liver > Flashcards

Aetiology & Pathophysiology of Liver Flashcards

1
Q

What are the zones of the liver?

A

1

2

3

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2
Q

Cirrhosis is the failure of the acute resolution of inflammation. T/F?

A

True

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3
Q

What are the causes of Cirrhosis?

A
  • Alcohol
  • Hepatitis C
  • Wilsons
  • Methotrexate
  • Haemochromatosis
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4
Q

What is Non alcoholic fatty liver disease?

A

Steato-hepatitis in absence of other cause

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5
Q

What is the pathogenesis involed NASH?

A

Excess triglyceride deposition, causes hepatocytes to generate TNFa.

Oxidative stress increases.

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6
Q

What investigations would you do for simple Steatosis and NASH?

A
  1. Steatosis- Ultrasound.
  2. NASH- Liver biopsy.
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7
Q

Management for Steatosis and NASH?

A
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8
Q
A
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9
Q

What is primary biliary cholangitis? (PBC)

A

Autoimmune disease- they contain anti-mitochondrial antibody, allowing it to be perfect marker for the disease.

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10
Q

How would PBC present?

A
  1. Asymptopmatic
  2. Fatigue
  3. Itch no rash
  4. Xanthelasma/xanthoma
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11
Q

Investigations and treatment for PBC

A
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12
Q

Auto-immune hepatitis affects men more than women.T/F?

A

False- Women. 40% of cases can cause Cirrhosis

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13
Q

What are the two types of Autoimmune hepatitis?

A
  • Type 1- Children & young adults. AMA defect.
  • Type 2- Adults. ANA defect. IgG elevated
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14
Q

What are complications of Autoimmune hepatitis?

A
  1. Autoimmune thyroiditis
  2. Chronic UC
  3. RA
  4. Lupus
  5. Systemic sclerosis
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15
Q

How does Autoimmune hepatitis present?

A
  1. Jaundice
  2. Hepatomegaly
  3. Splenomegaly
  4. Fatigue, malaise,nausea, abdo pain
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16
Q

Investigations for autoimmune hepatitis?

A
  • Antibody tests- check for elevated IgG, ANA, AMA
  • Liver biopsy
17
Q

What are the pathological findings in autoimmune hepatitis?

A

Chronic hepatitis- marked piecemeal Necrosis + Lobular involvement.

Numerous plasma cells.

Interface hepatitis- Hallmark finding

18
Q

What is the main treatment for Autoimmune hepatitis?

A
  • Corticosteroids
19
Q
A

GI-Week 6 (8 decks)

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