Adverse Reactions (Chapter 3)

Question 1

Drugs lack _____ specificity

Answer 1

absolute

Question 2

Therapeutic effects

Answer 2

clinically desirable actions

Question 3

Adverse effects

Answer 3

undesirable reactions; occurs at usual doses

Question 4

Toxic reaction

Answer 4

An extension of the pharmacologic effect

Question 5

Idiosyncratic

Answer 5

Genetically related abnormal drug response

Question 6

Drug allergy

Answer 6

immunologic response toa drug resulting in a reaction such as a rash or anaphylaxis. Neither predictable nor dose related!

Question 7

Interface with natural defense mechanisms

Answer 7

drug reduces body’s ability to fight infection

Question 8

Manifestations of Adverse Reactions (2)

Answer 8

Exaggerated effect on target tissues, effect on nontarget tissues.

Question 9

Safest drugs for pregnancy

Answer 9

penicillin, erythromycin, acetaminophen, local anesthetic lidocaine

Question 10

Contraindicated for pregnancy

Answer 10

tetracycline, nonsteroidal anti-inflammatory agents, benzodiazepines, metronidazole and epinephrine.