adverse drug Flashcards
most common type of drug eruption
exanthem or morbillaform rash
5 causes of uticaria
bugs, drugs, stress, food, ideopathic ( 85%)
differences in Uticaria from angioedema
AE occurs in mucosal surfaces of the mouth, lasts 2-3 day, painful
what does lesiosn on Erythema Multiforme llook like
target— syphalis immitates
pathology of EM
autoimmune reaction of skin — does not progress like TEN
treatment of EM
antihistamines, corticosteroids
SJS s/sx
sever widespread mucsal involvement along epidermal detachment – nikosky sign, skin hurts, occurs 7-21 days after drug started
TEN S/Sx
same as SJS just widespread greater than 30 BSA – acute onset of bullae and sloughing skin
Exfoliative Erythrodema
Red man syndrome– Diffuse erythema followed scalin g of skin
whast DRESS
Drug Rash with Eosinophilia and Sytemic Symptoms - severe skin rx with systemic symptoms— commonly form anticonvulsants and sulfonamides
DRESS sx /s
2-6 weeks after drug started— facial edema— liver problems kill most– tx is long term corticosteroids
fixed drug eruption
dusky or red macules then into plaques or bullae
common cause of FDR and tx
sulfa, NSaids, barbituates, tetracyclein,
topical steroids
immune complexes deposited in post capillary venules with palpable purpura
vasculitits
Vasculits sx and s
pin head size reddish puntae with cayeene pepper grain appeareance– not itchy– benign
