Advanced coatings Flashcards
1
Q
Why do we coat?
A
Aesthetics Mask taste Modify release Protection Improve mechanical properties
2
Q
Sugar coatings
A
Thick hard coating
Mask flavour
Protect from light and moisture imporving stability
3
Q
Film coating
A
Thin layer
Masks natural flavour, prevent from light and water
HPMC
4
Q
Film coating excipients
A
Polymers
Solvent
Platicizer - add flexibilty by lowering GTtemp
5
Q
Modified release
A
Repeat action - two doses
Slow release - released slowly
Controlled release - consistent and constant level
6
Q
MR candidates
A
Neither fast nor slow absorption uniformily absorbed small doses Good safety margin Chronic conditions
7
Q
Enteric coatings
A
Released in intestines Local or systemic action Protect from acid Protect stomach from drug Improve bioavailability
8
Q
Eudragits
A
Soluble at higher pHs, dissolve in intestines
More esters = higher pH solubility
