adrenocortical hormones Flashcards
what are the uses of aminoglutethemide
ttt of breast cancer
ttt of malignancies of the adrenal cortex
name 3 drugs that inhibit steroid synthesis
aminoglutethemide
ketoconazole
spironolactone
where is ketoconazole used as a steroid inhibitor
in cushings syndrome
what is the use of spironolatone as a steroid inhibitor
effective in hyperaldosteronism and hirsutism in women
SE of spironolactone
hyperkalemia, gynecomastia, menstrual irregularities
MOA of spironolactone as a steroid inhibitor
competes for mineralocorticoid receptor and inhibits sodium reabsorption
uses of betamethasone as a cream/oint
severe skin inflammation, eczema
use of flumetazone
ointment for chronic inflammatoy skin disorders
hyperkeratotic conditions
eczema
psoriasis vulgaris
uses of fluocininolone
synalar cream/oint for psoriasis and eczema
hydrocortisone
alfacort cream for mild inflammation
mometasone
elocom ointment sever inflammation of skin
dexamethasone decadron use
eye drop for local irritation of the eye
dexamethasone sofradex is a combination of? used for?
framycetin and gramicidin
otitis externa
prednisolone ultracortenol use?
allergic conjuctivitis
allergic rhinitis
inflamm in the eye
beclomethasone beconase use
allergic rhinitis
beclomethasone beconase dosage form
aerosol
name 3 adrenocorticol inhibitors for prophylaxis of asthma
fluticasone (flixotide)
beclomethasone (becotide)
budesonide
dexamethasone decadron tablets main use
diagnosis of cushings syndrome
cerebral edema
nausea and vomitting of chemotherapy
hydrocortone tablets main use
IBD and haemorrhoids
anaphylaxis RA
methylprednisolone main use
status asthmaticus
prednisolone main use
asthma
immunosuppression
fludrocortisone main use
adrenal hyperplasia and mineralocorticoid replacement in insufficiency
how long should corticosteroids be tapered after? why?
2 weeks. Sudden withdrawal of the drugs after prolonged therapy may result in acute adrenal insufficiency because of suppression of the patient’s capacity to synthesise corticosteroids.
dosage of adrenocorticosteroids is dependant on which 4 factors
Glucocorticoid vs mineralocorticoid activity
Duration of action
Type of preparation
Time of the day