adrenocortical hormones Flashcards
what are the uses of aminoglutethemide
ttt of breast cancer
ttt of malignancies of the adrenal cortex
name 3 drugs that inhibit steroid synthesis
aminoglutethemide
ketoconazole
spironolactone
where is ketoconazole used as a steroid inhibitor
in cushings syndrome
what is the use of spironolatone as a steroid inhibitor
effective in hyperaldosteronism and hirsutism in women
SE of spironolactone
hyperkalemia, gynecomastia, menstrual irregularities
MOA of spironolactone as a steroid inhibitor
competes for mineralocorticoid receptor and inhibits sodium reabsorption
uses of betamethasone as a cream/oint
severe skin inflammation, eczema
use of flumetazone
ointment for chronic inflammatoy skin disorders
hyperkeratotic conditions
eczema
psoriasis vulgaris
uses of fluocininolone
synalar cream/oint for psoriasis and eczema
hydrocortisone
alfacort cream for mild inflammation
mometasone
elocom ointment sever inflammation of skin
dexamethasone decadron use
eye drop for local irritation of the eye
dexamethasone sofradex is a combination of? used for?
framycetin and gramicidin
otitis externa
prednisolone ultracortenol use?
allergic conjuctivitis
allergic rhinitis
inflamm in the eye
beclomethasone beconase use
allergic rhinitis
beclomethasone beconase dosage form
aerosol
name 3 adrenocorticol inhibitors for prophylaxis of asthma
fluticasone (flixotide)
beclomethasone (becotide)
budesonide
dexamethasone decadron tablets main use
diagnosis of cushings syndrome
cerebral edema
nausea and vomitting of chemotherapy
hydrocortone tablets main use
IBD and haemorrhoids
anaphylaxis RA
methylprednisolone main use
status asthmaticus
prednisolone main use
asthma
immunosuppression
fludrocortisone main use
adrenal hyperplasia and mineralocorticoid replacement in insufficiency
how long should corticosteroids be tapered after? why?
2 weeks. Sudden withdrawal of the drugs after prolonged therapy may result in acute adrenal insufficiency because of suppression of the patient’s capacity to synthesise corticosteroids.
dosage of adrenocorticosteroids is dependant on which 4 factors
Glucocorticoid vs mineralocorticoid activity
Duration of action
Type of preparation
Time of the day
glucocorticoids combined with cytotoxic drugs for which disease
neoplastic disease
hogdkins lymphoma
acute lymphocytic leukemia
how is respiratory distress syndrome in fetus treated
administer beclomethasone Iv to mother 48 hours before birth and 24 hours after delivery
what is the dexamethasone suppression test used for
if cortisol is suppressed its cushings syndrome {pitituary dependent}
if cortisol {glucocorticoids} not suppressed it is adrenal tumors
what is cushings syndrome
hypersecretion of glucocorticoids
reasons for cushings syndrome
Excess corticotropin from pituitary
Adrenal tumor
Therapy for Secondary or Tertiary Adrenocortical Insufficiency
corticotropin or hydrocortisone
ttt for primary adrenal insufficiency with dosage regimen
hydrocortisone 2/3 dose in morning and 1/3 dose in the afternoon + fludrocortisone
glucocoticoids have _____________ actions where as mineralocortiocids have ____________.
inflammatory actions
salt retention properties
abdominal striae is a symptom of?
cushings syndrome
moon face is a symptom of
cushings syndrome
adrenal atrophy is a symptom of
addisons disease
mineralocorticoids cause reabsorption of and deabsorption of?
water, sodium bicarbonate
K+ and H+
elevated aldosterone causes?
hypokalemia, alkalosis, sodium water retention
hyperaldosteronism is treated with ___________.
spironolactone
chronic ttt with glucocorticoids may lead to osteoporosis. true of flase
true. negative calcium balance
name the main human glucocorticoid
cortisol, hydrocortisone
