adrenocortical hormones

Question 1

what are the uses of aminoglutethemide

Answer 1

ttt of breast cancer

ttt of malignancies of the adrenal cortex

Question 2

name 3 drugs that inhibit steroid synthesis

Answer 2

aminoglutethemide
ketoconazole
spironolactone

Question 3

where is ketoconazole used as a steroid inhibitor

Answer 3

in cushings syndrome

Question 4

what is the use of spironolatone as a steroid inhibitor

Answer 4

effective in hyperaldosteronism and hirsutism in women

Question 5

SE of spironolactone

Answer 5

hyperkalemia, gynecomastia, menstrual irregularities

Question 6

MOA of spironolactone as a steroid inhibitor

Answer 6

competes for mineralocorticoid receptor and inhibits sodium reabsorption

Question 7

uses of betamethasone as a cream/oint

Answer 7

severe skin inflammation, eczema

Question 8

use of flumetazone

Answer 8

ointment for chronic inflammatoy skin disorders
hyperkeratotic conditions
eczema
psoriasis vulgaris

Question 9

uses of fluocininolone

Answer 9

synalar cream/oint for psoriasis and eczema

Question 10

hydrocortisone

Answer 10

alfacort cream for mild inflammation

Question 11

mometasone

Answer 11

elocom ointment sever inflammation of skin

Question 12

dexamethasone decadron use

Answer 12

eye drop for local irritation of the eye

Question 13

dexamethasone sofradex is a combination of? used for?

Answer 13

framycetin and gramicidin

otitis externa

Question 14

prednisolone ultracortenol use?

Answer 14

allergic conjuctivitis
allergic rhinitis
inflamm in the eye

Question 15

beclomethasone beconase use

Answer 15

allergic rhinitis

Question 16

beclomethasone beconase dosage form

Answer 16

aerosol

Question 17

name 3 adrenocorticol inhibitors for prophylaxis of asthma

Answer 17

fluticasone (flixotide)
beclomethasone (becotide)
budesonide

Question 18

dexamethasone decadron tablets main use

Answer 18

diagnosis of cushings syndrome
cerebral edema
nausea and vomitting of chemotherapy

Question 19

hydrocortone tablets main use

Answer 19

IBD and haemorrhoids

anaphylaxis RA

Question 20

methylprednisolone main use

Answer 20

status asthmaticus

Question 21

prednisolone main use

Answer 21

asthma

immunosuppression

Question 22

fludrocortisone main use

Answer 22

adrenal hyperplasia and mineralocorticoid replacement in insufficiency

Question 23

how long should corticosteroids be tapered after? why?

Answer 23

2 weeks. Sudden withdrawal of the drugs after prolonged therapy may result in acute adrenal insufficiency because of suppression of the patient’s capacity to synthesise corticosteroids.

Question 24

dosage of adrenocorticosteroids is dependant on which 4 factors

Answer 24

Glucocorticoid vs mineralocorticoid activity
Duration of action
Type of preparation
Time of the day

Question 25

glucocorticoids combined with cytotoxic drugs for which disease

Answer 25

neoplastic disease
hogdkins lymphoma
acute lymphocytic leukemia

Question 26

how is respiratory distress syndrome in fetus treated

Answer 26

administer beclomethasone Iv to mother 48 hours before birth and 24 hours after delivery

Question 27

what is the dexamethasone suppression test used for

Answer 27

if cortisol is suppressed its cushings syndrome {pitituary dependent}
if cortisol {glucocorticoids} not suppressed it is adrenal tumors

Question 28

what is cushings syndrome

Answer 28

hypersecretion of glucocorticoids

Question 29

reasons for cushings syndrome

Answer 29

Excess corticotropin from pituitary

Adrenal tumor

Question 30

Therapy for Secondary or Tertiary Adrenocortical Insufficiency

Answer 30

corticotropin or hydrocortisone

Question 31

ttt for primary adrenal insufficiency with dosage regimen

Answer 31

hydrocortisone 2/3 dose in morning and 1/3 dose in the afternoon + fludrocortisone

Question 32

glucocoticoids have _____________ actions where as mineralocortiocids have ____________.

Answer 32

inflammatory actions

salt retention properties

Question 33

abdominal striae is a symptom of?

Answer 33

cushings syndrome

Question 34

moon face is a symptom of

Answer 34

cushings syndrome

Question 35

adrenal atrophy is a symptom of

Answer 35

addisons disease

Question 36

mineralocorticoids cause reabsorption of and deabsorption of?

Answer 36

water, sodium bicarbonate

K+ and H+

Question 37

elevated aldosterone causes?

Answer 37

hypokalemia, alkalosis, sodium water retention

Question 38

hyperaldosteronism is treated with ___________.

Answer 38

spironolactone

Question 39

chronic ttt with glucocorticoids may lead to osteoporosis. true of flase

Answer 39

true. negative calcium balance

Question 40

name the main human glucocorticoid

Answer 40

cortisol, hydrocortisone