adrenocortical hormones Flashcards

1
Q

what are the uses of aminoglutethemide

A

ttt of breast cancer

ttt of malignancies of the adrenal cortex

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2
Q

name 3 drugs that inhibit steroid synthesis

A

aminoglutethemide
ketoconazole
spironolactone

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3
Q

where is ketoconazole used as a steroid inhibitor

A

in cushings syndrome

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4
Q

what is the use of spironolatone as a steroid inhibitor

A

effective in hyperaldosteronism and hirsutism in women

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5
Q

SE of spironolactone

A

hyperkalemia, gynecomastia, menstrual irregularities

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6
Q

MOA of spironolactone as a steroid inhibitor

A

competes for mineralocorticoid receptor and inhibits sodium reabsorption

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7
Q

uses of betamethasone as a cream/oint

A

severe skin inflammation, eczema

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8
Q

use of flumetazone

A

ointment for chronic inflammatoy skin disorders
hyperkeratotic conditions
eczema
psoriasis vulgaris

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9
Q

uses of fluocininolone

A

synalar cream/oint for psoriasis and eczema

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10
Q

hydrocortisone

A

alfacort cream for mild inflammation

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11
Q

mometasone

A

elocom ointment sever inflammation of skin

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12
Q

dexamethasone decadron use

A

eye drop for local irritation of the eye

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13
Q

dexamethasone sofradex is a combination of? used for?

A

framycetin and gramicidin

otitis externa

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14
Q

prednisolone ultracortenol use?

A

allergic conjuctivitis
allergic rhinitis
inflamm in the eye

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15
Q

beclomethasone beconase use

A

allergic rhinitis

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16
Q

beclomethasone beconase dosage form

A

aerosol

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17
Q

name 3 adrenocorticol inhibitors for prophylaxis of asthma

A

fluticasone (flixotide)
beclomethasone (becotide)
budesonide

18
Q

dexamethasone decadron tablets main use

A

diagnosis of cushings syndrome
cerebral edema
nausea and vomitting of chemotherapy

19
Q

hydrocortone tablets main use

A

IBD and haemorrhoids

anaphylaxis RA

20
Q

methylprednisolone main use

A

status asthmaticus

21
Q

prednisolone main use

A

asthma

immunosuppression

22
Q

fludrocortisone main use

A

adrenal hyperplasia and mineralocorticoid replacement in insufficiency

23
Q

how long should corticosteroids be tapered after? why?

A

2 weeks. Sudden withdrawal of the drugs after prolonged therapy may result in acute adrenal insufficiency because of suppression of the patient’s capacity to synthesise corticosteroids.

24
Q

dosage of adrenocorticosteroids is dependant on which 4 factors

A

Glucocorticoid vs mineralocorticoid activity
Duration of action
Type of preparation
Time of the day

25
glucocorticoids combined with cytotoxic drugs for which disease
neoplastic disease hogdkins lymphoma acute lymphocytic leukemia
26
how is respiratory distress syndrome in fetus treated
administer beclomethasone Iv to mother 48 hours before birth and 24 hours after delivery
27
what is the dexamethasone suppression test used for
if cortisol is suppressed its cushings syndrome {pitituary dependent} if cortisol {glucocorticoids} not suppressed it is adrenal tumors
28
what is cushings syndrome
hypersecretion of glucocorticoids
29
reasons for cushings syndrome
Excess corticotropin from pituitary | Adrenal tumor
30
Therapy for Secondary or Tertiary Adrenocortical Insufficiency
corticotropin or hydrocortisone
31
ttt for primary adrenal insufficiency with dosage regimen
hydrocortisone 2/3 dose in morning and 1/3 dose in the afternoon + fludrocortisone
32
glucocoticoids have _____________ actions where as mineralocortiocids have ____________.
inflammatory actions | salt retention properties
33
abdominal striae is a symptom of?
cushings syndrome
34
moon face is a symptom of
cushings syndrome
35
adrenal atrophy is a symptom of
addisons disease
36
mineralocorticoids cause reabsorption of and deabsorption of?
water, sodium bicarbonate | K+ and H+
37
elevated aldosterone causes?
hypokalemia, alkalosis, sodium water retention
38
hyperaldosteronism is treated with ___________.
spironolactone
39
chronic ttt with glucocorticoids may lead to osteoporosis. true of flase
true. negative calcium balance
40
name the main human glucocorticoid
cortisol, hydrocortisone