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ANS Pharmacology > Adrenoceptor Agonists > Flashcards

Adrenoceptor Agonists Flashcards

1
Q

Methyldopa

A
  1. Presynaptic alpha 2 agonists
  2. Hypertension
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2
Q

Adrenoceptor Agonists:

A

Direct acting adrenoceptor agonist (Catecholamine):

  • Dopamine
  • Epinephrine
  • Norepinephrine
  • Isoproterenol
  • Dobutamine

Non-Catecholamine:

  • Clonidine
  • Oxymetazoline
  • Midodrine
  • Phenylephrine
  • Ritodrine
  • Albuterol
  • Apraclonidine

Mnemonic: COMP Right At Aua

Indirect Acting Adrenoceptor Agonists:

  • Amphetamine
  • Cocaine

Mixed Acting Adrenoceptor agonists:

  • Ephedrine
  • Pseudoephedrine
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3
Q

Phenylephrine

A
  1. alpha 1 Agonists
  2. Decongestant

Note: Causes Mydriasis without cycloplegia and Reflex bradycardia

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4
Q

Methoxamine

A
  1. alpha 1 Agonists
  2. PAT (paroxysmal atrial tachycardia)
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5
Q

Clonidine

A
  1. alpha 2 Agonists
  2. hypertension
  3. decrease in BP
  4. Rebound “overshoot” hypertension when discontinued
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6
Q

Alpha-methyl dopa

A
  1. alpha 2 Agonists
  2. prodrug
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7
Q

Dobutamine

A
  1. B1>B2 Agonists
  2. acute CHF
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8
Q

Isoproterenol

A
  1. B1 = B2 Agonists
  2. Bronchospasm
  3. Flushing, arrhythmias
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9
Q

Metaproterenol

A
  1. B2 Agonists 3. Bronchodilator
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10
Q

Albuterol

A
  1. B2 Agonists 2. acute asthma
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11
Q

Salmetrol

A
  1. B2 Agonists 2. Asthma prophylaxis 3. long acting bronchodilator
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12
Q

Terbutaline

A
  1. B2 Agonists 3. Bronchodilator and Tocolytics
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13
Q

Ritodrine

A
  1. B2 Agonists
  2. Prevent premature labor
  3. Tocolytics
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14
Q

Norepinephrine

A
  1. Mixed alpha and beta agonists
  2. alpha1, alpha 2, and B1.

B1: Increase cardiac contractility

Increased heart rate by B1 is overcome by alpha 1’s vasoconstriction –> reflex bradycardia

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15
Q

Epinephrine

A
  1. Mixed alpha and beta agonists
  2. Anaphylactic shock, cardiac arrest
  3. alpha1, alpha2, B1, and B2.

In Low doses B are more sensitive. B1 increase contractility and heart rate. B2 –> vasodilation –> decrease TPR (No reflex).

In High doses alpha predominates. alpha1 –> vasoconstriction –> increase TPR, Reflex bradycardia

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16
Q

Tyramine

A
  1. Indirect acting Adrenoceptor agonists
  2. hypertensive crisis with MAO inhibitors
17
Q

Dopamine

A
  1. Indirect acting Adrenoceptor agonists

2.

  1. Low dose (D1): Increase RBF and GFR.

Medium dose (D1, B1): increase CO.

Large dose (B1 and alpha 1): Vasoconstriction

ANS Pharmacology (6 decks)

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