Adrenergic Receptors Flashcards
Alpha 1
Gq
Incr: vascular SM contraction. Mydriasis. Prostate contraction. Heart contraction force.
Alpha 2
Gi
Decr: sympathetic outflow, insulin release, lipolysis, aqueous humor production
Incr: platelet aggregation
Beta 1
Gs - Heart
Incr: HR, contractility, renin, lipolysis
Beta 2
Gs - SM relaxation
Incr: Vasodilation, bronchodilation, lipolysis, insulin release, glycogenolysis, aqueous humor production.
Beta 3
Gs
Incr: lipolysis, thermogenesis, bladder relaxation
D1
Gs
Relaxes renal vascular SM. Activates direct pathway of striatum
D2
Gi
Modulates NT release, inhibits direct pathway of striatum.
Vascular SM contraciton
a1
Mydriasis
a1
Increased contraction force
a1
Decreased adrenergic outflow
a2
Reduced BP
a2
B2
Reduced HR
a2
Platelet aggregation
a2
Increased BP
a1
B1 - renin