Adrenergic Drugs Flashcards
Direct Adrenergic Agonists
Alpha: Phenylephrine Clonidine Mixed alpha and beta: NE Epi Beta: Dobutamine Isoproterenol Albuterol Dopamine Fenoldopam
Phenylephrine
a1>a2 agonist
Clonidine
a2>a1 agonist
Norepinephrine
a1, a2, B1 agonist
Epinephrine
a1, a2, B1, B2 agonist
Dobutamine
B1>B2 agonist
Isoproterenol
B1, B2 agonist
Albuterol
B2»B1 agonist
Dopamine
D1, D2 agonist
D1: vasodilation of Renal, Cerebral, Mesenteric, and Coronary arteries. Fenoldopam.
D2: inhibits NE release
Indirect Adrenergic Agonists
Cocaine Phenelzine Selegiline Amphetamine Methylphenidate Ephedrine Tyramine
Cocaine
DA/NE reuptake inhibitor
Phenelzine
MAO inhibitor
Incr. NE in CNS
Antidepressant
Amphetamine
DA/NE reuptake inhibitor
Increases release of DA & NE
ADHD
Selegiline
MAO inhibitor
Incr. NE in CNS
Antidepressant
Methylphenidate
DA/NE reuptake inhibitor
Increases release of DA & NE
ADHD
Ephedrine
Indirect general agonist, releases stored NE/DA
Tyramine
Release of stored NE.
Risk of incr BP with MAOIs
Adrenergic Antagonists
Alpha nonselective: Phentolamine Phenoxybenzamine Alpha 1: -osin Mixed: a1, B1, B2 Labet-alol Carved-ilol Beta: -olol B1 selective = A to M Nonselective = N to Z
Acebutolol Atenolol Betaxolol Bisoprolol Esmolol Metoprolol
B1 antagonist
Nadolol
Pindolol
Propranolol
Timolol
B1, B2 antagonist
Beta Blocker Antagonists
ANtagonistic PeanutButter Atenolol Nadolol Propranolol Betaxolol
Beta Blocker Partial Agonists
PArtiaL
Pindolol
Acebutolol
Labetalol
Beta Blocker Inverse Agonists
CM
Carvedilol
Metoprolol
