Adrenergic Receptor Need-To-Know Table Information Flashcards
Alpha-1 (G-Alpha-q)
Tissue Location
- Major Blood Vessels
- Dermal
- GI
- Renal
- Bladder
- Nasal
- Eye
- Bladder Sphinters
- GI Sphincters
Alpha-1 (G-Alpha-q)
Primary Effects on Major Blood Vessels
- Constriction
- Increase peripheral resistance
- Increase diastolic blood pressure
Alpha-1 (G-Alpha-q)
Primary Effects on the Eye
- Contraction of radial muscle (Mydriasis)
Alpha-1 (G-Alpha-q)
Primary Effects on the Bladder/GI Sphincters
- Contrict Sphincters
- Decrease outflow
Alpha-2 (G-Alpha-i)
Tissue Location
- Eye
- Pancreatic Islets
- Presynaptic nerve terminals
- Brainstem
- Spinal cord
- Nasal Vasculature
Alpha-2 (G-Alpha-i)
Primary Effects on the Eye
- Decrease production of aqueous humor
Alpha-2 (G-Alpha-i)
Primary Effects on Pancreatic Islets
- Decrease insulin release
- Increase blood glucose
Alpha-2 (G-Alpha-i)
Primary Effects on Presynaptic Nerve Terminals
- Decrease neurotransmitter release
Alpha-2 (G-Alpha-i)
Primary Effects on the Brainstem
- Decrease blood pressure
- Inhibit baroreflex
Alpha-2 (G-Alpha-i)
Primary Effects on the Spinal Cord
- Inhibit pain transmission
Alpha-2 (G-Alpha-i)
Primary Effects on Nasal Vasculature
- Contriction
Beta-1 (G-Alpha-s)
Tissue Location
- Heart
- Kindey
- Eye
Beta-1 (G-Alpha-s)
Primary Effect on the Heart
- Increase heart rate
- Increase contractility
- Increase force
- Increace cardiac ouput
Beta-1 (G-Alpha-s)
Primary Effect on the Kidneys
- Increase renin secretion
- vasoconstriction
Beta-1 (G-Alpha-s)
Primary Effect on the Eyes
- Increase production of aquesous humor
Beta-2 (G-Alpha-s)
Tissue Location
- Vascular smooth muscle to liver and skeletal muscle
- Pulmonary smooth muscle
- GI long smooth muscle
- Bladder detrusor muscle
- Pregnant uterus (myometrium)
- Skeletal muscle
- Mast cells
- Pancreas
- Liver
- Eyes
Beta-2 (G-Alpha-s)
Primary Effect on Vascular Smooth Muscle to the Liver and Skeletal Muscle
- Relaxation
- Increase blood flow to liver and skeletal muscle
Beta-2 (G-Alpha-s)
Primary Effect on Pulmonary Smooth Muscle
- Relaxation
- Increased airflow
Beta-2 (G-Alpha-s)
Primary Effect on GI Long Smooth Muscle
- Relaxation
- Decreased motility
Beta-2 (G-Alpha-s)
Primary Effect on the Bladder Detrusor Muscle
- Relaxation
- Decrease outflow
Beta-2 (G-Alpha-s)
Primary Effect on a Pregnant Uterus
- Relaxation
Beta-2 (G-Alpha-s)
Primary Effect on Skeletal Muscle
- Increased glucogenolysis
- Increase K+ uptake
Beta-2 (G-Alpha-s)
Primary Effect on Mast Cells
- Decrease degranulation
Beta-2 (G-Alpha-s)
Primary Effect on the Pancreas
- Increase glucagon secretion
Beta-2 (G-Alpha-s)
Primary Effect on the Liver
- Increase glycogenolysis
- Increase blood glucose
Beta-2 (G-Alpha-s)
Primary Effect on the Eyes
- Increase production of aqueous humor
Beta-3 (G-Alpha-s)
Tissue Location and Primary Effect
- Fat
- Lipolysis (complex process)
