Adrenergic Receptor Need-To-Know Table Information

Question 1

Alpha-1 (G-Alpha-q)

Tissue Location

Answer 1

• Major Blood Vessels
  
  • Dermal
  • GI
  • Renal
  • Bladder
  • Nasal
• Eye
• Bladder Sphinters
• GI Sphincters

Question 2

Alpha-1 (G-Alpha-q)

Primary Effects on Major Blood Vessels

Answer 2

• Constriction
• Increase peripheral resistance
• Increase ­diastolic blood pressure

Question 3

Alpha-1 (G-Alpha-q)

Primary Effects on the Eye

Answer 3

• Contraction of radial muscle (Mydriasis)

Question 4

Alpha-1 (G-Alpha-q)

Primary Effects on the Bladder/GI Sphincters

Answer 4

• Contrict Sphincters
• Decrease outflow

Question 5

Alpha-2 (G-Alpha-i)

Tissue Location

Answer 5

• Eye
• Pancreatic Islets
• Presynaptic nerve terminals
• Brainstem
• Spinal cord
• Nasal Vasculature

Question 6

Alpha-2 (G-Alpha-i)

Primary Effects on the Eye

Answer 6

• Decrease production of aqueous humor

Question 7

Alpha-2 (G-Alpha-i)

Primary Effects on Pancreatic Islets

Answer 7

• Decrease insulin release
• Increase blood glucose

Question 8

Alpha-2 (G-Alpha-i)

Primary Effects on Presynaptic Nerve Terminals

Answer 8

• Decrease neurotransmitter release

Question 9

Alpha-2 (G-Alpha-i)

Primary Effects on the Brainstem

Answer 9

• Decrease blood pressure
• Inhibit baroreflex

Question 10

Alpha-2 (G-Alpha-i)

Primary Effects on the Spinal Cord

Answer 10

• Inhibit pain transmission

Question 11

Alpha-2 (G-Alpha-i)

Primary Effects on Nasal Vasculature

Answer 11

• Contriction

Question 12

Beta-1 (G-Alpha-s)

Tissue Location

Answer 12

• Heart
• Kindey
• Eye

Question 13

Beta-1 (G-Alpha-s)

Primary Effect on the Heart

Answer 13

• Increase heart rate
• Increase contractility
• Increase force
• Increace cardiac ouput

Question 14

Beta-1 (G-Alpha-s)

Primary Effect on the Kidneys

Answer 14

• Increase renin secretion
  
  • vasoconstriction

Question 15

Beta-1 (G-Alpha-s)

Primary Effect on the Eyes

Answer 15

• Increase production of aquesous humor

Question 16

Beta-2 (G-Alpha-s)

Tissue Location

Answer 16

• Vascular smooth muscle to liver and skeletal muscle
• Pulmonary smooth muscle
• GI long smooth muscle
• Bladder detrusor muscle
• Pregnant uterus (myometrium)
• Skeletal muscle
• Mast cells
• Pancreas
• Liver
• Eyes

Question 17

Beta-2 (G-Alpha-s)

Primary Effect on Vascular Smooth Muscle to the Liver and Skeletal Muscle

Answer 17

• Relaxation
• Increase blood flow to liver and skeletal muscle

Question 18

Beta-2 (G-Alpha-s)

Primary Effect on Pulmonary Smooth Muscle

Answer 18

• Relaxation
  
  • Increased airflow

Question 19

Beta-2 (G-Alpha-s)

Primary Effect on GI Long Smooth Muscle

Answer 19

• Relaxation
  
  • Decreased motility

Question 20

Beta-2 (G-Alpha-s)

Primary Effect on the Bladder Detrusor Muscle

Answer 20

• Relaxation
  
  • Decrease outflow

Question 21

Beta-2 (G-Alpha-s)

Primary Effect on a Pregnant Uterus

Answer 21

• Relaxation

Question 22

Beta-2 (G-Alpha-s)

Primary Effect on Skeletal Muscle

Answer 22

• Increased glucogenolysis
• Increase K⁺ uptake

Question 23

Beta-2 (G-Alpha-s)

Primary Effect on Mast Cells

Answer 23

• Decrease degranulation

Question 24

Beta-2 (G-Alpha-s)

Primary Effect on the Pancreas

Answer 24

• Increase glucagon secretion

Question 25

Beta-2 (G-Alpha-s)

Primary Effect on the Liver

Answer 25

• Increase glycogenolysis
  
  • Increase blood glucose

Question 26

Beta-2 (G-Alpha-s)

Primary Effect on the Eyes

Answer 26

• Increase production of aqueous humor

Question 27

Beta-3 (G-Alpha-s)

Tissue Location and Primary Effect

Answer 27

• Fat
  
  • Lipolysis (complex process)