Adrenergic Receptor Antagonists

Question 1

Clinical Use of Alpha Blockers

Answer 1

Hypertension
Prostate Hyperplasia (decrease urinary flow resistance)

Raynaud’s Disease
Phaeochromocytoma

Prev: Erectile dysfunction: inject. into corpus callosum

Question 2

Nonselective Alpha Blockers

Answer 2

Phentolamine: competitive inhibitor
1st hypertensive drug; causes reflex tachy

Phenoxybenzamine: noncompetitve inhibitor
also irreversible uptake-1 inhibitor
Used: phaeochromocytoma

Dihydroergotamine
Migrane th

Question 3

Selective Alpha 1 Blocker

Answer 3

Tamsulosin
prostate hyperplasia

Prazosin
prototype

Terazosine

Doxazosine

Question 4

Selective Alpha 2 Blocker

Answer 4

Mirtazapine: antidepressant

Question 5

Mixed Alpha and Beta Antagonists

Answer 5

Labetolol (hypertensive crisis) , carvedilol (CHF)
–>alpha 1 and beta

Urapidil
alpha 1 antagonist and 5HT agonist
doesn’t induce reflex tachy

Question 6

General SEs of Alpha Blockers

Answer 6

Reflex Tachycardia
Orthostatic Hypotension: inhibition of normal vasocon
reflex
Diarrhoea: increased peristalsis

Question 7

Medical Uses of Beta Blockers

Answer 7

Hypertension
Angina Pectoris
SV and Ventricular Arrhythmia
Glaucoma
Tremor and Anxiety

Question 8

Nonselective Beta Blockers

Answer 8

Propranolol: Migrane, performance anxiety, essential
tremor

Timolol: Glaucoma
Acebutolol: Antiarrythmic Class II
Pindolol: also partial agonist at 5HT1A
((Nadolol))

Question 9

Beta 1 Selective

Answer 9

Celiprolol: Beta 2 Agonist

Bisoprolol
Esmolol
Atenolol
Acebutolol
Metoprolol

Question 10

Basis for Glucagon Usage

Answer 10

Positive ino- and chronotropic via glucagon R (Gs)

Use in beta blocker overdose

(Atropine is inconsistant in reversing bradycardia and hypotension induced by beta blockers)