Adrenergic Drugs Flashcards
Phenylephrine
alpha-1 Agonist
Clonidine
Alpha-2 Agonist
Prazosin
Alpha-1 Antagonist
Doxazosin
Alpha-1 Antagonist
Tamsulosin
Alpha-1 Antagonist
Phentolamine
Alpha Antagonist (a1 & a2)
Phenoxybenzamine
Alpha Antagonist (a1 & a2)
Epinephrine
Alpha and Beta Direct Agonist (a1, a2, B1, B2)
Norepinephrine
Alpha and Beta Direct Agonist (a1, a2, B1)
Cocaine
Alpha and Beta Indirect Agonist (inhibits DA/NE/E re-uptake)
Amphetamine/Methamphetamine
Alpha and Beta Indirect Agonist (inhibits DA/NE/E re-uptake and increases their release)
Methylphenidate
Alpha and Beta Indirect Agonist (inhibits DA/NE/E re-uptake and increases their release)
Ephedrine
Alpha and Beta Indirect Agonist (stimulates the release of DA/NE/E)
Tyramine
Alpha and Beta Indirect Agonist (stimulates the release of NE)
Phenelzine/Selegiline
Alpha and Beta Indirect Agonist (inhibit MAO, increasing concentration of DA/NE/E in the CNS)
Labetolol
Alpha and Beta Partial Agonist (a1, B1, B2)
Carvedilol
Alpha and Beta Inverse Agonist (a1, B1, B2)
Isoproterenol
Beta Agonist (B1, B2)
Dobutamine
B1 Agonist
Albuterol
B2 Agonist
Pindolol
Beta Partial Agonist (B1, B2)
Acebutolol
B1 Partial Agonist
Propanolol
Beta Antagonist (B1, B2)
Nadolol
Beta Antagonist (B1, B2)
Atenolol
B1 Antagonist
Betaxolol
B1 Antagonist
Metoprolol
B1 Inverse Agonist
What G Protein are the following coupled to? a1 = a2 = B1 = B2 =
a1 = Gq a2 = Gi B1 = Gs B2 = Gs
What G protein are the following coupled to? D1 = D2 = D3 = D4 = D5 =
D1 = Gs D2 = Gi D3 = Gi D4 = Gi D5 = Gs
At Physiological levels, what does the D1 Receptor for DA do?
What about at higher levels?
What about at even HIGHER levels?
At Physiological Levels, D1 receptor activation causes Vasodilation
At higher levels it activates B1 AR’s in the heart
At even HIGHER levels it activates vascular a1 AR’s to cause vasoconstriction
What effect does DA have when binding to Presynaptic D2 Receptors?
When DA binds to presynaptic D2 Receptors it suppresses NE release, leading to a decreased sympathetic outflow
Activation of which Adrenergic receptor will cause an increased secretion of Renin from Kidney JG Cells?
B1
Activation of which Adrenergic receptor will cause decreased secretion of Aqueous Humor?
a2
Activation of which Adrenergic receptor will cause increased secretion and decreased outflow of Aqueous Humor?
B2
If you want to cause Mydriasis (Dilation) in a patient’s eye but do not want to alter normal accommodation, what Adrenergic Receptor would you want to stimulate?
a1
What adrenergic Drug would be your go to for treating Acute Cardiac failure? What Receptor does it target? Why do we want to target that receptor?
Dobutamine
It Targets B1
Stimulating B1 Receptors will increase Cardiac Output which will help with Acute Cardiac Failure