Adrenergic Drugs

Question 1

Phenylephrine

Answer 1

alpha-1 Agonist

Question 2

Clonidine

Answer 2

Alpha-2 Agonist

Question 3

Prazosin

Answer 3

Alpha-1 Antagonist

Question 4

Doxazosin

Answer 4

Alpha-1 Antagonist

Question 5

Tamsulosin

Answer 5

Alpha-1 Antagonist

Question 6

Phentolamine

Answer 6

Alpha Antagonist (a1 & a2)

Question 7

Phenoxybenzamine

Answer 7

Alpha Antagonist (a1 & a2)

Question 8

Epinephrine

Answer 8

Alpha and Beta Direct Agonist (a1, a2, B1, B2)

Question 9

Norepinephrine

Answer 9

Alpha and Beta Direct Agonist (a1, a2, B1)

Question 10

Cocaine

Answer 10

Alpha and Beta Indirect Agonist (inhibits DA/NE/E re-uptake)

Question 11

Amphetamine/Methamphetamine

Answer 11

Alpha and Beta Indirect Agonist (inhibits DA/NE/E re-uptake and increases their release)

Question 12

Methylphenidate

Answer 12

Alpha and Beta Indirect Agonist (inhibits DA/NE/E re-uptake and increases their release)

Question 13

Ephedrine

Answer 13

Alpha and Beta Indirect Agonist (stimulates the release of DA/NE/E)

Question 14

Tyramine

Answer 14

Alpha and Beta Indirect Agonist (stimulates the release of NE)

Question 15

Phenelzine/Selegiline

Answer 15

Alpha and Beta Indirect Agonist (inhibit MAO, increasing concentration of DA/NE/E in the CNS)

Question 16

Labetolol

Answer 16

Alpha and Beta Partial Agonist (a1, B1, B2)

Question 17

Carvedilol

Answer 17

Alpha and Beta Inverse Agonist (a1, B1, B2)

Question 18

Isoproterenol

Answer 18

Beta Agonist (B1, B2)

Question 19

Dobutamine

Answer 19

B1 Agonist

Question 20

Albuterol

Answer 20

B2 Agonist

Question 21

Pindolol

Answer 21

Beta Partial Agonist (B1, B2)

Question 22

Acebutolol

Answer 22

B1 Partial Agonist

Question 23

Propanolol

Answer 23

Beta Antagonist (B1, B2)

Question 24

Nadolol

Answer 24

Beta Antagonist (B1, B2)

Question 25

Atenolol

Answer 25

B1 Antagonist

Question 26

Betaxolol

Answer 26

B1 Antagonist

Question 27

Metoprolol

Answer 27

B1 Inverse Agonist

Question 28

What G Protein are the following coupled to?
a1 = 
a2 = 
B1 = 
B2 =

Answer 28

a1 = Gq
a2 = Gi
B1 = Gs
B2 = Gs

Question 29

What G protein are the following coupled to?
D1 = 
D2 = 
D3 = 
D4 = 
D5 =

Answer 29

D1 = Gs
D2 = Gi
D3 = Gi
D4 = Gi
D5 = Gs

Question 30

At Physiological levels, what does the D1 Receptor for DA do?
What about at higher levels?
What about at even HIGHER levels?

Answer 30

At Physiological Levels, D1 receptor activation causes Vasodilation

At higher levels it activates B1 AR’s in the heart

At even HIGHER levels it activates vascular a1 AR’s to cause vasoconstriction

Question 31

What effect does DA have when binding to Presynaptic D2 Receptors?

Answer 31

When DA binds to presynaptic D2 Receptors it suppresses NE release, leading to a decreased sympathetic outflow

Question 32

Activation of which Adrenergic receptor will cause an increased secretion of Renin from Kidney JG Cells?

Answer 32

B1

Question 33

Activation of which Adrenergic receptor will cause decreased secretion of Aqueous Humor?

Answer 33

a2

Question 34

Activation of which Adrenergic receptor will cause increased secretion and decreased outflow of Aqueous Humor?

Answer 34

B2

Question 35

If you want to cause Mydriasis (Dilation) in a patient’s eye but do not want to alter normal accommodation, what Adrenergic Receptor would you want to stimulate?

Answer 35

a1

Question 36

What adrenergic Drug would be your go to for treating Acute Cardiac failure? What Receptor does it target? Why do we want to target that receptor?

Answer 36

Dobutamine

It Targets B1

Stimulating B1 Receptors will increase Cardiac Output which will help with Acute Cardiac Failure