adrenergic drugs

Question 1

what nervous system and subsequently function does the adrenergic ns mediate?

Answer 1

sympathetic

Question 2

outline the adrenergic receptors, where they are located, and their function.

Answer 2

alpha
a1:
- smooth muscle
- vasoconstriction, pupil dilation, bladder sphincter contraction

a2:
- presynaptic nerve terminals, CNS, platelets
- inhibits norepinephrine release (neg feedback), reduces sympathetic outflow, promotes platelet aggregation

beta
b1:
- heart, kidneys
- inc heart rate and contractility, stimulates renin release from the kidneys

b2:
- smooth muscle, skeletal muscle and liver
- bronchodilation, vasodilation in skeletal muscle vesselss, inc glycogenolysis and gluconeogenesis

Question 3

adrenergic receptors are activated by NE and epinephrine, where are these released from to activate the receptors?

Answer 3

• NE is released from postganglionic fibres to activate adrenergic receptors
• epinephrine released from adrenal medulla

Question 4

name clinical uses for stimulating alpha receotors and name the agonist.

Answer 4

• allergic reaction
• anaphylaxis
• cardiac arrest

(Adrenaline)

Question 5

name the clinical uses for blocking alpha receptors and name the antagonists.

Answer 5

a1:
- vasodilation - treats hypertension
- doxazosin

a2:
- relaxation of bladder and prostate smooth muscle - treats bladder outflow obstruction
- tamsulosin

Question 6

name the clinical uses of stimulating beta receptors and name the agonists.

Answer 6

b1:
- inc force and rate of cardiac muscle contraction - treats heart failure
- dobutamine

b2:
- bronchial dilation - treats asthma
- salbutamol

Question 7

name the clinical uses for blocking beta receptors and name the antagonists.

Answer 7

b1:
- reduces force and rate of contraction - treats hypertension
- atenolol