adrenergic blockers

Question 1

non selective alpha blockers

Answer 1

Phenoxybenzamine*

Phentolamine*

Question 2

Alpha1 selective blockers

Answer 2

Prazosin*
Terazosin
Tamsulosin*
Doxazosin

Treat BPH, were used to treat htn

Question 3

Ergot Alkaloids Alpha blockers

Answer 3

ergotamine

ergonovine

Question 4

Alpha2 selective blockers

Answer 4

Yohimbine

Question 5

Non selective beta blockers

Answer 5

Propranolol*
nadolol
timolol
Pindolol
Carteolol

Question 6

Cardioselective beta blockers

Answer 6

Beta1blockers
Atenolol
acebutolol
metoprolol
betaxolol

Question 7

Very short acting beta blockers

Answer 7

Esmolol

Question 8

Alpha and beta blockers

Answer 8

Labetalol

carvedilol

Question 9

Phenoxybenzamine

Answer 9

irreversible a1 and a2 blocker
noncompetitive
dirty also blocks histamine ach and serotonin receptors
reduces bp
se is orthostatic hypotension, reflex tachycardia from bp being reduced, crosses bbb causing nausea vomiting and weakness, inhbits ejac, miosis stuffy nose (all alpha 1 blockade
reynauds
give with pheochromocytome along with beta blocker

Question 10

Phentolamine

Answer 10

Reversible a1 and a2 blocker
competitive
several hours
histamine also
pheochromocytoma, clonidine withdrawal, necrosis due to ne and pe, ed
se are tachycardia nausea diarrhea and orthostatic hypotension

Question 11

Prazosin

Answer 11

Selective a1 blocker

Question 12

Tamsulosin

Answer 12

selective a1a blocker
little vascular effects but good for bph
prostate are alpha1a

Question 13

ergots

Answer 13

dirty blockers
spoiled rye
causes abortions gangrene and convulsions

Question 14

Yohimbine

Answer 14

selective a2 blocker
also blocks 5ht
aphrodisiac and treats ed

Question 15

propranolol

Answer 15

nonselective beta bocker
treats angina pectoris, htn, migraine prophylaxis, arrhythmias, thyrotoxicosis, pheochromocytoma, anxiety attacks, chf
high lipid - drowsiness
membrane stabilizing
decreases hr, co, exercise tolerance, o2 demand, av nodal conduction, mi size and reinfaction, and pacemaker activity
slow to decrease peripheral resistance
se - dizziness, fatigue, diarrhea, constipation, nausea, depression, bizarre dreams, purpura, rash and fever, and increases cholesterol
contraindicated in asthma bc it blocks bronchodilation
masks hypoglycemia and can induce hypclycemia
titrate does 75% inactivated at first pass
cant withdraw suddenly get htn angina or mi
contraindicated in acute decompensated heart failure, 2nd and 3rd degree block and cardiogenic shock
DI - hypotensive, anti-arrhythmic, insulin and hyperthyroid meds

Question 16

timolol

Answer 16

nonselective beta blocker
more potent than propranolol
lowers iop in glaucoma

Question 17

pindolol

Answer 17

nonselective beta blocker
parial agonist
intrinsit sympathomimetic activity
less rebound htn and bradycardia than propranolol
like carteolol

Question 18

nadolol

Answer 18

nonselective beta blocker

Question 19

atenolol

Answer 19

b1 blocker - prototype

all b1 blockers lessen bronchospasm risk, still contraindicated in asthma, they do not prolong hypoglycemia

Question 20

acebutolol

Answer 20

b1 blocker
partial agonist isa
partial agonist
htn
dysrhythmias

Question 21

metoprolol

Answer 21

b1 blocker
htn
chf

Question 22

betaxolol

Answer 22

b1 blocker

glaucoma

Question 23

esmolol

Answer 23

short acting beta1 blocker
used during surgery for tachycardia htn and arrhythmias
electroconvulsive therapy

Question 24

labetolol

Answer 24

alpha1 and beta1 and 2 blocker

htn and pheochromocytoma

Question 25

carvedilol

Answer 25

alpha and beta blocker both nonselective
lipid soluble
antioxidant properties
chf

Question 26

bisoprolol

Answer 26

b1 blocker

chf