Adrenergic antagonists

Question 1

Adrenergic Antagonists AKA?

Answer 1

adrenergic blockers or sympatholytics

Question 2

Adrenergic Antagonists Reversibly or irreversibly bind to receptor but do NOT trigger the usual effects of the endogenous ______

Answer 2

catecholamines

Question 3

how are Adrenergic Antagonists classified?

Answer 3

Classified, like the agonists, according to their affinity for alpha or beta receptors

Question 4

Non-selective drugs in this class can profoundly affect BP

Answer 4

Alpha-adrenergic Receptor Antagonists

Question 5

in Alpha-adrenergic Receptor Antagonists, Blockade of α receptors reduces sympathetic tone of blood vessels resulting in decreased ________

Answer 5

peripheral vascular resistance

Question 6

Blockade of α receptors reduces sympathetic tone of blood vessels resulting in decreased peripheral vascular resistance. This induces a reflex tachycardia and the magnitude of the response depends on the_____of the individual.

Answer 6

sympathetic tone

Question 7

Blockade of α receptors reduces sympathetic tone of blood vessels resulting in decreased peripheral vascular resistance. This induces a reflex tachycardia and the magnitude of the response depends on the sympathetic tone of the individual.

Effects are more profound in an individual who is standing versus supine
_____patients will also have a more marked response

Answer 7

Hypovolemic

Question 8

CV Drugs that block α1-receptors

Answer 8

Doxazosin (Cardura)
Prazosin (Minipress)
Terazosin (Hytrin)

Question 9

BPH Drugs that block α1-receptors

Answer 9

Alfuzosin (Uroxatral)
Silodosin (Rapaflo)
Tamsulosin (Flomax)

Question 10

Alpha-adrenergic Receptor Antagonists Misc- special uses?

Answer 10

Phenoxybenzamine (Dibenzyline) - pheochromocytoma

Phentolamine (OraVerse) – pheochromocytoma and NE extravasation

Question 11

Prazosin, terazosin, and doxazosin
 are what class of drugs?

Answer 11

Alpha-adrenergic Receptor Antagonists

Question 12

Alpha-adrenergic Receptor Antagonists CV effects:

Answer 12

Relaxation of arterial and venous smooth muscle
Can cause profound orthostatic hypotension with first-dose
- Need to reduce first dose and dose at bedtime

Question 13

Alpha-adrenergic Receptor Antagonists ADRs

Answer 13

Dizziness
Fatigue
Nasal congestion
HA
Orthostatic hypotension
Sexual dysfunction

Question 14

Beta-adrenergic Receptor Antagonists can be distinguished by the following properties:

Answer 14

• Relative affinity for β1 and β2 receptors
• Intrinsic sympathomimetic activity
• Blockade of α receptors
• Differences in lipid solubility
• Capacity to induce vasodilation
• Pharmacokinetic parameters

Question 15

these block both β1 and β2 receptors

Answer 15

Nonselective: block both β1 and β2 receptors

Question 16

these primarily block β1 receptors

Answer 16

Selective (or cardioselective): primarily block β1 receptors

Question 17

are there any clinically useful β2 antagonists

Answer 17

There are no clinically useful β2 antagonists

Question 18

Antihypertensive Effects of Beta Blockers: The release of renin from the juxtaglomerular apparatus is stimulated by the sympathetic nervous system by means of_____, and this effect is blocked by receptor antagonists

Answer 18

β1 receptors

Question 19

receptor antagonists are effective even in patients with low plasma renin, and _____ is an effective antihypertensive agent that has little or no effect on plasma renin activity

Answer 19

pindolol