Adrenergic Antagonists

Question 1

7.1 A 60-year-old female patient started on a new antihypertensive medication recently. Her blood
pressure seems to be under control, but she complains
of fatigue, drowsiness, and fainting when she gets up from the bed (orthostatic hypotension). Which of the following drugs is she most likely taking?

Answer 1

C. Prazosin.

Question 2

7.2 A 30-year-old male patient was brought to the ER with amphetamine overdose. He presented with high blood pressure and arrhythmia. Which of the following is
correct regarding this patient?

Answer 2

A. Amphetamine can activate all types of adrenergic receptors.

Question 3

7.3 A new antihypertensive drug was tested in an animal model of hypertension. The drug when given alone reduces blood pressure in the animal. Norepinephrine when given in the presence of this drug did not cause any significant change in blood pressure or heart
rate in the animal. The new drug is similar to which
of the following drugs in terms of its pharmacological mechanism of action?

Answer 3

E. Carvedilol

Question 4

7.4 A β-blocker was prescribed for hypertension in a female asthma patient. After about a week of treatment, the asthma attacks got worse, and the patient was asked
to stop taking the β-blocker. Which of the following β-blockers would you suggest as an alternative in this patient that is less likely to worsen her asthma?

Answer 4

B. Metoprolol.

Question 5

7.5 A 70-year-old male needs to be treated with an α-blocker for overflow incontinence due to his enlarged prostate. Which of the following drugs would you
suggest in this patent that will not affect his blood
pressure significantly?

Answer 5

D. Tamsulosin.

Question 6

7.6 A 50-year-old male was brought to the emergency room after being stung by a hornet. The patient was found to
be in anaphylactic shock, and the medical team tried to reverse the bronchoconstriction and hypotension
using epinephrine. However, the patient did not fully respond to the epinephrine treatment. The patient’s wife mentioned that he is taking a prescription medication
for his blood pressure, the name of which she does not remember. Which of the following medications is he
most likely taking that could have prevented the effects of epinephrine?

Answer 6

B. Propranolol

Question 7

7.7 Which of the following is correct regarding α-adrenergic blockers?

Answer 7

B. α-Adrenergic blockers are used in the treatment of benign prostatic hyperplasia (BPH).

Question 8

7.8 Which of the following is correct regarding β-blockers?

Answer 8

A. Treatment with β-blockers should not be stopped abruptly.

Question 9

7.9 Which of the following drugs is commonly used topically in the treatment of glaucoma?

Answer 9

B. Timolol.

Question 10

7.10 Which of the following is correct regarding carvedilol?

Answer 10

C. Carvedilol has α1-blocking activity.