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Pharm Unit 2 > Adrenergic Antagonists > Flashcards

Adrenergic Antagonists Flashcards

1
Q

Class and action of phentolamine and phenoxybenzamine

A

non-selective alpha antagonists (alpha1+2);

vasodilation, decrease TPR, decrease BP

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2
Q

Therapeutic use of phentolamine and phenoxybenzamine

A

pheochromocytoma, Raynauds, frostbite

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3
Q

Side effects of phentolamine and phenoxybenzamine

A

postural hypotension, inhibit ejaculation

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4
Q

Class and action of prazosin

A

alpha1-selective antagonist;

vasodilation, decrease TPR, decrease BP

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5
Q

Therapeutic use of prazosin

A

primary HTN, BPH

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6
Q

Side effects of prazosin

A

postural hypotension (usually first-dose)

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7
Q

Class and action of propranolol and timolol

A

first generation non-selective beta antagonists (beta1+2);

decrease HR, decrease contractility, decrease CO

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8
Q

Therapeutic use of propranolol and timolol

A

angina, HTN, arrhythmias

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9
Q

Side effects of propranolol and timolol

A

bradycardia, bronchoconstriction, sexual dysfunction

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10
Q

Class and action of metoprolol and atenolol

A

2nd generation beta1-selective antagonists;

decrease HR, contractility, CO

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11
Q

Therapeutic use of metoprolol and atenolol

A

HTN, angina, arrhythmias

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12
Q

Side effects of metoprolol and atenolol

A

bradycardia, sexual dysfunction

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13
Q

Class and action of carvedilol and labetalol

A

3rd generation non-selective beta antagonists;

decrease HR, CO

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14
Q

Therapeutic use of carvedilol and labetalol

A

CHF, HTN

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15
Q

Side effects of carvedilol and labetalol

A

bradycardia, fatigue

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16
Q

Class and action of betaxolol

A

3rd generation beta1-selective antagonist;

decrease HR, CO

17
Q

Therapeutic use of betaxolol

18
Q

Side effects of betaxolol

A

bradycardia

19
Q

Class and action of guanethidine

A

nerve ending blocker; vesicles full of this instead of NE

20
Q

Therapeutic use of guanethidine

21
Q

Side effects of guanethidine

A

many and serious

22
Q

Class and action of alpha-methyltyrosine

A

nerve ending blocker; inhibit tyrosine hydroxylase, decreasing NE synthesis

23
Q

Therapeutic use of alpha-methyltyrosine

A

pheochromocytoma

24
Q

Side effects of alpha-methyltyrosine

A

many and serious

25
Q

Class and action of reserpine

A

nerve ending blocker; release of empty vesicles bc NE blocked from entering them

26
Q

Therapeutic use of reserpine

A

HTN (older drug)

27
Q

Side effects of reserpine

A

serious clinical depression (suicide possible); many and serious side effects

Pharm Unit 2 (10 decks)

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