Adrenergic Agonists Flashcards
Class and action of norepi.
non-selective agonist (alpha1+2, beta1);
vasoconstriction, increase BP, direct increase HR, reflex decrease HR
Therapeutic use of norepi.
hypotension
Side effects of norepi.
hypertension, arrhythmias, HA
Class and action of epi.
non-selective agonist (alpha1+2, beta1+2);
increase HR, increase contractility, increase BP, reflex decrease HR
Therapeutic use of epi.
anaphylactic shock, with local anesthetics, glaucoma
Side effects of epi.
palpitation, arrhythmias, HA, tremor
Class and action of isoproterenol.
non-selective beta agonist (beta1+2);
decrease resistance, increase cardiac output, increase HR, bronchodilation
Therapeutic use of isoproterenol.
bronchodilator/asthma, shock, heart block
Side effects of isoproterenol.
palpitation, tachyarrhythmias, HA
Class and action of dobutamine.
beta1-selective agonist;
increase contractility, increase HR, direct increase HR
Therapeutic use of dobutamine.
cardiac decompensation, shock, heart block
Side effects of dobutamine.
tachyarrhythmias, HTN
Class and action of albuterol and terbutaline.
beta2-selective agonists;
relax bronchial and uterine smooth muscle
Therapeutic use of albuterol and terbutaline.
bronchodilator/asthma, COPD
early labor
Side effects of albuterol and terbutaline.
tachycardia, muscle tremor
Class and action of phenylephrine and ephedrine
alpha1-selective agonist;
vasoconstriction
Therapeutic use of phenylephrine and ephedrine
nasal congestion, postural hypotension
Side effects of phenylephrine and ephedrine
HTN, reflex bradycardia
Class and action of clonidine, alpha-methyldopa
alpha2-selective agonist;
decrease sympathetic outflow from CNS, decrease TPR
Therapeutic use of clonidine, alpha-methyldopa
HTN, shock, withdrawal from drug dependence
Side effects of clonidine, alpha-methyldopa
sedation
Class and action of fenoldopam
DA (D1)-selective agonist;
vasodilation
Therapeutic use of fenoldopam
HTN emergency, anuria
Side effects of fenoldopam
postural hypotension
Class and action of amphetamine
indirect-acting, release NE;
CNS stimulation, increase BP, increase HR
Therapeutic use of amphetamine
ADHD, narcolepsy, recreation
Side effects of amphetamine
HTN, insomnia, anxiety, arrhythmias
Class and action of dopamine
Mixed acting: direct (D1, beta1, alpha1) and indirect (NE release);
vasodilation, increase GFR, increase HR, increase BP
(increasing dose leads to addition of beta1 and then alpha1 effects)
Therapeutic use of dopamine
shock, renal failure, hypotension
Side effects of dopamine
vasoconstriction (at high doses)
