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Adrenergic and Cholinergic receptors Flashcards

1
Q

Adrenergic receptors bind

A

Catecholamines (NE and EPI)

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2
Q

Catecholamines

A

NE and EPI

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3
Q

Steps to synthesize catecholamines

A

Tyrosine to DOPA to dopamine to NE to EPI

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4
Q

Where does synthesis of catecholamines occur

A

Nerve terminal

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5
Q

Where are catecholamines stored

A

Synaptic vesicles

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6
Q

Location of adrenergic receptors

A

Postsynaptic membrane

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7
Q

How catecholamines are inactivated

A

Reuptake with VMAT or degradation with MOA

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8
Q

Types of adrenergic receptors

A

Alpha and Beta

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9
Q

What type of receptor are adrenergic receptors

A

G-coupled protein

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10
Q

Types of alpha receptors

A

Alpha 1 and Alpha 2

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11
Q

How alpha 1 stimulates

A

Post-synaptically stimulates phospholipase C and causes vasoconstriction/pupil dilation

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12
Q

Activation of alpha 1 causes

A

Contraction of muscles

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13
Q

Alpha 1 receptors located at…

A

Vasculature
Dilator pupillae
Internal urethral sphincter

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14
Q

Alpha 1 stimulation of vasculature

A

Vasoconstriction - increased BP and increase in TPR

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15
Q

Alpha one dilator pupillae

A

Pupil dilation

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16
Q

Alpha 1 on internal ureteral sphincter

A

Contraction

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17
Q

Alpha 2 receptor location

A

NE nerve terminal

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18
Q

Alpha 2 action

A

Inhibitory, activation of these receptors decreases amount of NE released

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19
Q

Beta adrenergic receptor type

A

G protein coupled

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20
Q

What do Beta receptors mediate

A

Relaxation or decreased activity

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21
Q

Types of beta receptors

A

Beta 1 and Beta 2

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22
Q

Where are beta 1 receptors

A

Heart

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23
Q

Beta 1 receptors on heart

A

Act on SA and AV nodes to increase HR and conduction velocity
Increase contractility and stroke volume

24
Q

Beta 2 receptors location

A

Vascular
Bronchial smooth muscle
Detrusor (bladder)

25
Q

Beta 2 on vascular

A

Vasodilation decreases TPR and increases CO

26
Q

Beta 2 bronchial

A

Bronchodilation

27
Q

Beta 2 bladder

A

Relaxation (stretch and fill)

28
Q

Impact level of NE and EPI on adrenergic receptors

A

NE stimulates alpha more than beta
EPI stimulates alpha and beta equally

29
Q

Removal of NE and EPI

A

NorEpinephrine transporter (NET
Takes up from the synapse
Diffusion
Degradation into inactive metabolites by MOA and COMT

30
Q

Time of activation NE

A

Seconds and rapid reuptake and diffusion

31
Q

Time of activation EPI

A

Several minutes

32
Q

ABCD

A

Alpha constrict with NE
Beta dilates with epi

33
Q

Cholinergic receptor

34
Q

Types of cholinergic receptors

A

Muscarinic and nicotinic

35
Q

Synthesis of ACh

A

Acetyl coA and choline via ChAT

36
Q

Where is ACh stored

A

Vesicles in the terminal axon

37
Q

How is ACh released

A

AP causes Ca influx and SNARE complex activation which fuses the vesicle containing ACh

38
Q

Inactivation of ACh through

A

Acetylcholinesterase

39
Q

What type of channel is nicotinic

A

Ligand gated

40
Q

Nicotinic receptor location

A

Neuromuscular junction

41
Q

Activation of nicotinic receptor

A

Depolarizes skeletal muscle causing contraction

42
Q

Nicotinic neuronal receptor location

A

ANS ganglia
Adrenal medulla
CNS

43
Q

Nn ANS ganglia

A

Depolarizes post synaptic neurons and mediates effects of pre-ganglionic ANS neurons

44
Q

Nn Adrenal medulla

A

Catecholamine release

45
Q

Muscarinic receptor type

A

G protein coupled receptor

46
Q

Overall action of muscarinic receptors

A

Parasympathetic innervation

47
Q

Types of muscarinic receptors

48
Q

Location of M2 receptors

49
Q

Activation of M2 receptor

A

SA and AV node to decrease HR and conduction velocity
Increasing vagal tone to elongate AP slope

50
Q

Location of M3 receptors

A

Sweat glands
Respiratory system
GI tract
Urinary bladder
Eye

51
Q

M3 sweat glands

A

Secretion (only one that is sympathetic ACh activation)

52
Q

M3 respiratory system

A

Bronchoconstriction and increased secretions

53
Q

M3 GI tract

A

Increase salivation, secretion, peristalsis
Relax sphincters

54
Q

M3 Urinary bladder

A

Urinate
Contract bladder and relax sphincter

55
Q

M3 eye

A

Contraction (pupil constriction)
Tear production

56
Q

AChe cleaves into

A

Acetate ion and choline

57
Q

AChR

A

Acetylcholinesterase is adjacent to cholinergic receptors and is primary way ACh is terminated

Physiology (5 decks)

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