Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

Physiology > Adrenergic and Cholinergic receptors > Flashcards

Adrenergic and Cholinergic receptors Flashcards

1
Q

Adrenergic receptors bind

A

Catecholamines (NE and EPI)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Catecholamines

A

NE and EPI

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Steps to synthesize catecholamines

A

Tyrosine to DOPA to dopamine to NE to EPI

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Where does synthesis of catecholamines occur

A

Nerve terminal

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Where are catecholamines stored

A

Synaptic vesicles

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Location of adrenergic receptors

A

Postsynaptic membrane

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

How catecholamines are inactivated

A

Reuptake with VMAT or degradation with MOA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Types of adrenergic receptors

A

Alpha and Beta

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What type of receptor are adrenergic receptors

A

G-coupled protein

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Types of alpha receptors

A

Alpha 1 and Alpha 2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

How alpha 1 stimulates

A

Post-synaptically stimulates phospholipase C and causes vasoconstriction/pupil dilation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Activation of alpha 1 causes

A

Contraction of muscles

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Alpha 1 receptors located at…

A

Vasculature
Dilator pupillae
Internal urethral sphincter

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Alpha 1 stimulation of vasculature

A

Vasoconstriction - increased BP and increase in TPR

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Alpha one dilator pupillae

A

Pupil dilation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Alpha 1 on internal ureteral sphincter

A

Contraction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Alpha 2 receptor location

A

NE nerve terminal

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Alpha 2 action

A

Inhibitory, activation of these receptors decreases amount of NE released

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Beta adrenergic receptor type

A

G protein coupled

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

What do Beta receptors mediate

A

Relaxation or decreased activity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Types of beta receptors

A

Beta 1 and Beta 2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Where are beta 1 receptors

A

Heart

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Beta 1 receptors on heart

A

Act on SA and AV nodes to increase HR and conduction velocity
Increase contractility and stroke volume

24
Q

Beta 2 receptors location

A

Vascular
Bronchial smooth muscle
Detrusor (bladder)

25
Beta 2 on vascular
Vasodilation decreases TPR and increases CO
26
Beta 2 bronchial
Bronchodilation
27
Beta 2 bladder
Relaxation (stretch and fill)
28
Impact level of NE and EPI on adrenergic receptors
NE stimulates alpha more than beta EPI stimulates alpha and beta equally
29
Removal of NE and EPI
NorEpinephrine transporter (NET Takes up from the synapse Diffusion Degradation into inactive metabolites by MOA and COMT
30
Time of activation NE
Seconds and rapid reuptake and diffusion
31
Time of activation EPI
Several minutes
32
ABCD
Alpha constrict with NE Beta dilates with epi
33
Cholinergic receptor
Binds ACh
34
Types of cholinergic receptors
Muscarinic and nicotinic
35
Synthesis of ACh
Acetyl coA and choline via ChAT
36
Where is ACh stored
Vesicles in the terminal axon
37
How is ACh released
AP causes Ca influx and SNARE complex activation which fuses the vesicle containing ACh
38
Inactivation of ACh through
Acetylcholinesterase
39
What type of channel is nicotinic
Ligand gated
40
Nicotinic receptor location
Neuromuscular junction
41
Activation of nicotinic receptor
Depolarizes skeletal muscle causing contraction
42
Nicotinic neuronal receptor location
ANS ganglia Adrenal medulla CNS
43
Nn ANS ganglia
Depolarizes post synaptic neurons and mediates effects of pre-ganglionic ANS neurons
44
Nn Adrenal medulla
Catecholamine release
45
Muscarinic receptor type
G protein coupled receptor
46
Overall action of muscarinic receptors
Parasympathetic innervation
47
Types of muscarinic receptors
M2 and M3
48
Location of M2 receptors
Heart
49
Activation of M2 receptor
SA and AV node to decrease HR and conduction velocity Increasing vagal tone to elongate AP slope
50
Location of M3 receptors
Sweat glands Respiratory system GI tract Urinary bladder Eye
51
M3 sweat glands
Secretion (only one that is sympathetic ACh activation)
52
M3 respiratory system
Bronchoconstriction and increased secretions
53
M3 GI tract
Increase salivation, secretion, peristalsis Relax sphincters
54
M3 Urinary bladder
Urinate Contract bladder and relax sphincter
55
M3 eye
Contraction (pupil constriction) Tear production
56
AChe cleaves into
Acetate ion and choline
57
AChR
Acetylcholinesterase is adjacent to cholinergic receptors and is primary way ACh is terminated

Physiology (5 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions