Adrenergic Agonists

Question 1

Reuptake is inhibited by (3 drugs)

Answer 1

1- cocaine
2- Tricyclic
3- imipramine( antidepressant)

Question 2

Increase Renin release by which receptor?

Answer 2

B1 receptor = then causes increase in BP.

Question 3

Increase glycogenolysis & gluconeogenesis occurs by which receptor?

Answer 3

α1 & B2 receptor

Question 4

Increase production of aqueous humor by which receptor?

Answer 4

B2 receptor in the ciliary epitheliam .

Question 5

Powerful cardiac stimulant is

Answer 5

Epinephrine. Also it increases O2 consumption. So it is CI in Angina.

Question 6

A drug mediate increases systolic pressure and decreases diastolic pressure is

Answer 6

Epinephrine.
Isoprenaline

Question 7

A drug Inhibits release of histamine is

Answer 7

Epinephrine

Question 8

Physiological antagonist of histamine

Answer 8

Epinephrine

Question 9

The indication of epinephrine (6 uses)

Answer 9

1- anaphylactic shock
2- cardiac arrest
3- cardiogenic shock.
4- local hemostatics
5- combined with local anesthetics
6- bronchospasm.

Question 10

The adverse effects of epinephrine on CVS &CNS

Answer 10

CVS: tachycardia, angina , hypertension, cerebral hemorrhage , coldness extremities.

CNS: headache, restlessness, nasal stuffiness.

Question 11

The CI of epinephrine ( 4 points)

Answer 11

1- cardiovascular disease
2- hypertension
3- hyperthyroidism
4- diabetes mellitus.

Question 12

A drug mediate increases in both systolic pressure and diastolic pressure is (3 drugs)

Answer 12

Norepinephrine + amphetamine.

Question 13

Reflex bradycardia as a result of using

Answer 13

Norepinephrine

Question 14

Use in cases of Shock

Answer 14

Norepinephrine (NE) : causes increase both systolic (SBP) & diastolic pressure (DBP)

Question 15

Adverse effects of norepinephrine

Answer 15

Potent V.C can cause blanching of skin, tissue necrosis. impaired circulation can be treated with phentolamine (non selective α blocker) or terbutaline (selective B2 agonist)

Question 16

The DOC in cardiogenic shock and septic shock

Answer 16

Dopamine

Question 17

Selective D1 agonists

Answer 17

Fenoldopam

Question 18

Used in hypertensive emergency

Answer 18

Fenoldopam

Question 19

Use in acute heart failure.

Answer 19

Dobutamine : ⬆️ H.R without O2 consumption

Question 20

α1&2 agonist

Answer 20

Oxymetazoline

Question 21

Therapeutic use of oxymetazoline (2 uses)

Answer 21

to relief Nasal congestion and ophthalmic redness .

Question 22

Adverse effects of oxymetazoline

Answer 22

Rebound congestion, local irritation and sneezing , nervousness.

Question 23

Rebound Nasal congestion caused by

Answer 23

Oxymetazoline , Phenylephrine.

Question 24

Used in (hypotensive) emergency.

Answer 24

Phenylephrine

Question 25

Clinical use of phenylephrine (3 points)

Answer 25

1- mydriatic agent .
2- decongestant agent
3- vasopressor agent.

Question 26

Used in orthostatic hypotension.

Answer 26

Midodrine (α1 agonist )

Question 27

used in hypertension in pregnancy. ⭐️ ⭐️

Answer 27

α methyldopa .

Question 28

The uses of clonidine & α methyldopa

Answer 28

Treatment of hypertension
To Minimize the symptoms of withdrawal of opiates and tobacco smoking.

Question 29

Used as a uterine relaxant

Answer 29

Terbutaline , Ritodrine (selective B2 agonists)

Question 30

Therapeutic uses of salbutamol & terbutaline ( 2 uses)

Answer 30

1- salbutamol for management of asthma
2- terbutaline to relax the muscles of Uterus.

Question 31

Used for patients with overactive bladder.

Answer 31

Mirabegron ( selective B3 agonist)

Question 32

Therapeutic uses of amphetamine.(3uses)

Answer 32

Obesity ( phentermine)
Attention deficit hyperactivity disorder (Methylphenidate)
Narcolepsy . (Modafinil)

Question 33

Therapeutic uses of cocaine

Answer 33

Local anesthetics

Question 34

The uses of ephedrine

Answer 34

Increase BP
Bronchodilator.
Stimulates CNS

Question 35

The uses of pseudoephedrine

Answer 35

Nasal and sinus decongestant