Adrenergic Agents-HTN and HF Drugs

Question 1

Prozasin

Answer 1

Adrenergic Agent
Therapeutic Use – Dilation of arterioles and veins to treat hypertension
Mechanism – α1-adrenergic antagonist

Adverse effects:
reflex tachycardia

Question 2

Metoprolol

Answer 2

Adrenergic Agent
Indication: hypertension, angina, MI, HF
Mechanism: blocks ß1 receptors (“cardioselective”), decreasing heart rate, AV conduction, contractility; also reduces ß1-mediated renin release in the kidney

Adverse Effects: rebound cardiac excitement, block caution in heart block and HF

Question 3

Clonidine

Answer 3

Adrenergic Agent
Indication: hypertension (resistant form)
Mechanism: central α2 activation in the brainstem sympathetic outflow (by enhancing feedback inhibition of NE release)

Adverse Effects: 
CNS effects (nightmares, anxiety and depression)

Question 4

Reserpine

Answer 4

Adrenergic Agent
Indication: Hypertension
MOA: Depletion of NE from presynaptic sympathetic neurons-reduce alpha and beta-receptor effects leading to vasodilation and slowing of the heart

Side Effect: Depression

Full week for effect