Adrenergic Agents Flashcards
Phenylephrine
Direct Sympathomimetic
a1 > a2
Mydriasis (ocular procedures)
Nasal Decongestant
Severe Hypotension and Shock
Clonidine
Direct Sympatholytic
a2 agonist
Use: Hypertensive Urgency
CNS: Depression
Decreased release of Norepi
Decreased CO and Vasoconstriction
Isoproterenol
Direct Sympathomimetic
B1 = B2
Use: Torsades (long QT)
Albuterol
Direct Sympathomimetic
SABA
B2 > B1
Bronchodilation
Use: Asthma
Methyldopa
Direct Sympatholytic
a2 agonist
Use: Hypertensive Urgency
CNS: Depression
Decreased release of Norepi
Decreased CO and Vasoconstriction
Phenoxybenzamine
Irreversible a-Blocker
Uses: Pheochromocytoma (prior to surgery)
Phentolamine
Reversible a-Antagonist
Uses: Diagnosis of Pheochromocytoma
(patients will experience a larger than expected decrease in BP following administration)
Prazosin
Selective a1-Antagonist (“-osin”)
Peripheral vascular smooth muscle relaxation
Uses: BPH (reduced prostatic/bladder contraction)
NOTE: First Dose Syncope (severe orthostatic hypotension)
Propranolol
Non-Selective B-Blocker
B1 = B2
Side Effects: Bronchoconstriction Fasting Hypoglycemia (B2 blockers decrease glycogenolysis)
Carvedilol
Non-Selective a1, B1, B2 receptor blocker
Uses: CHF
Metoprolol
Selective B1-antagonist
Decreases HR and Contractility
Uses: HTN, CAD, Tachycardias
Epinephrine
Direct Sympathomimetic
B > a
Uses: Anaphylaxis, Asthma, Open Angle Glaucoma
Norepinephrine
Direct Sympathomimetic
a1,2 > B1
Uses: Severe Hypotension
Dopamine
Direct Sympathomimetic
D > B > a
D receptors promote renal perfusion
Uses: Severe Hypotension
Dobutamine
Direct Sympathomimetic
B1 > B2, a
Uses: Heart Failure
