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DRUG BRUTE FORCE MEMORIZATION > Adrenergic > Flashcards

Adrenergic Flashcards

1
Q

Epinephrin

A

Indication: Anaphylaxis, cardiac arrest, bronchospasm
MoA: a and B agonist
Adverse Effects: ARRYTHMIAS, cerebral hemorrhage, anxiety, cold extremities, pulmonary edema
Contraindications: Late term pregnancy
Misc:
Low dose-> lower diastolic BP (B2), increased CO (B1)
High dose -> INcrease TPR and CO (a1+a2+B1) bronchodilation (B2), decreased bronchial secretions (a1)

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2
Q

Norepinephrine

A

Indication: Shock
MoA: a-agonist, B1-agonist
Adverse Effects: Arrythmias, ISCHEMIA, hypertension
Contraindications: PRE-EXISTING VASOCONSTRICTION OR ISCHEMIA, late term pregnancy
Misc: Increase CO (B1), increas TPR (a1+a2), decrease HR (baroreflex), overall increase in MAP

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3
Q

Dopamine

A

Indication: Cardiogenic shock
MoA: B-agonist, some a-agonist activity (D1>D2>B1>a1>a2)
Adverse Effects: LOW BP (at low infusion rates), ISCHEMIA (high infusion rates)
Contraindications: Tachyarrhythmias, v-fib
Misc:
Low rates: decreases TPR (D1), increases CO (B1)
Higher rates: increases MAP and TPR (a1+a2+B1), D1 in renal/splanchnic vascular beds -> protects from ischmia

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4
Q

Isoproterenol

A

Indication: Bradycardia/heart block when TPR is high
MoA: B-agonist
Adverse Effects: TACHYARRYTHMIAS
Contraindications: ANGINA WITH ARRYTHMIAS
Misc: Decrease TPR (B2), increase CO (B1), small decrease in MAP, bronchodilation (B2)

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5
Q

Dobutamine

A

Indication: SHORT TERM TX FOR CHF OR CARDIOGENIC SHOCK, excess B-blockade
MoA: B1-agonist
Adverse Effects: Arrythmias (B1), HYPOTENSION (B2)
Contraindications:
Misc:Increase CO (B1), B1>B2>a

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6
Q

Terbutaline and albuterol

A

Indication: Bronchospasm, chronic rx of obstructive airway disorder
MoA: B2-agonist
Adverse Effects: TACHYCARDIA (B1), MUSCLE TREMOR (B2), TOLERANCE (B2)
Contraindications:
Misc: Bronchodilation and uterine relaxation

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7
Q

Phenylephrine

A

Indication: Hypotension during anestheisa, SV tachycardia, mydriatic agent in opthalmic rx, nasal congestion
MoA: a1-agonist
Adverse Effects: HYPERTENSION
Contraindications: Hypertension, v-tach
Misc: Increase TPR and MAP, decrease HR (via baroreflec), pupillary dilation, decrease bronchiole and sinus secretions, no COMT degredation

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8
Q

Clonidine

A

Indication: Hypertension d/t sympathetic activation
MoA: a2-agonist
Adverse Effects: DRY MOUTH, sedation, bradycardia, HYPERTENSIVE CRISIS (after acute withdrawal)
Contraindications:
Misc: Acute increase in BP (peripheral effect), reduced BP (central effect), a2 receptors in CNS on sympathetic neurons, inhibit these and reduce sympathetic drive

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9
Q

Amphetamine

A

Indication: ADHD
MoA: Indirect sympathomimetic
Adverse Effects: TACHYCARDIA, anxiety
Contraindications: hypertension, hx drug abuse, RX WITH MAO INHIBITORS
Misc: Increase TPR and diastolic BP (a1+a2), positive inotropic and chronotropic effects (B1), increase systolic pressure, CNS stimulant (increased NE)

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10
Q

Methylphenidate

A

Indication: ADHD
MoA: Indirect sympathomimetic
Adverse Effects: TACHYCARDIA, anxiety
Contraindications: hypertension, hx drug abuse, RX WITH MAO INHIBITORS
Misc: Increase TPR and diastolic BP (a1+a2), positive inotropic and chronotropic effects (B1), increase systolic pressure, CNS stimulant (increased NE)

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11
Q

Ephedrine

A

Indication: Pressor agent with anesthesia
MoA: Indirect sympathomimetic
Adverse Effects: TACHYCARDIA, anxiety
Contraindications: hypertension, hx drug abuse, RX WITH MAO INHIBITORS
Misc: Increase TPR and diastolic BP (a1+a2), positive inotropic and chronotropic effects (B1), increase systolic pressure, CNS stimulant (increased NE)

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12
Q

Pseudoephedrine

A

Indication: Nasal decongestion
MoA: Indirect sympathomimetic
Adverse Effects: TACHYCARDIA, anxiety
Contraindications: hypertension, hx drug abuse, RX WITH MAO INHIBITORS
Misc: Increase TPR and diastolic BP (a1+a2), positive inotropic and chronotropic effects (B1), increase systolic pressure, CNS stimulant (increased NE)

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13
Q

Propranolol

A

Indication: Hypertension, angina d/t atherosclerosis, MI
MoA: B-blocker
Adverse Effects: BRONCHOSPASM, MASKS SYMPTOMS OF HYPOGLYCEMIA, insomnia, depression, BRADYCARDIA
Contraindications: BRONCHOSPASM DURING ASTHMA, SINUS BRADYCARDIA, 2/3 DEGREE HEART BLOCK, CARDIOGENIC SHOCK
Misc: Decreased HR, decreased contractility, decreased renin release, reduced sympathetic activation, inhibition of aqueous humor production

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14
Q

Timolol

A

Indication: Glaucoma
MoA: B-blocker
Adverse Effects: BRONCHOSPASM, MASKS SYMPTOMS OF HYPOGLYCEMIA, insomnia, depression, BRADYCARDIA
Contraindications: BRONCHOSPASM DURING ASTHMA, SINUS BRADYCARDIA, 2/3 DEGREE HEART BLOCK, CARDIOGENIC SHOCK
Misc: Decreased HR, decreased contractility, decreased renin release, reduced sympathetic activation, inhibition of aqueous humor production

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15
Q

Nadolol

A

Indication: Long-term angina
MoA: B-blocker
Adverse Effects: BRONCHOSPASM, MASKS SYMPTOMS OF HYPOGLYCEMIA, insomnia, depression, BRADYCARDIA
Contraindications: BRONCHOSPASM DURING ASTHMA, SINUS BRADYCARDIA, 2/3 DEGREE HEART BLOCK, CARDIOGENIC SHOCK
Misc: Decreased HR, decreased contractility, decreased renin release, reduced sympathetic activation, inhibition of aqueous humor production

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16
Q

Atenolol

A

Indication: Hypertension, angina, MI
MoA: B1-blocker
Adverse Effects: Dizziness, depression, insomnia, HYPOTENSION, BRADYCARDIA
Contraindications: SINUS BRADYCARDIA, 2/3 DEGREE HEART BLOCK, CARDIOGENIC SHOCK, severe heart failure
Misc: Decreased HR, decreased contractility, decreased renin release, reduced sympathetic activation

17
Q

Metoprolol

A

Indication: Hypertension, long-term angina
MoA: B1-blocker
Adverse Effects: Dizziness, depression, insomnia, HYPOTENSION, BRADYCARDIA
Contraindications: SINUS BRADYCARDIA, 2/3 DEGREE HEART BLOCK, CARDIOGENIC SHOCK, severe heart failure
Misc: Decreased HR, decreased contractility, decreased renin release, reduced sympathetic activation

18
Q

Esmolol

A

Indication: Supraventricular tachycardia
MoA: B1-blocker
Adverse Effects: Dizziness, depression, insomnia, HYPOTENSION, BRADYCARDIA
Contraindications: SINUS BRADYCARDIA, 2/3 DEGREE HEART BLOCK, CARDIOGENIC SHOCK, severe heart failure
Misc: Decreased HR, decreased contractility, decreased renin release, reduced sympathetic activation

19
Q

Pindolol

A

Indication: Hypertension
MoA: B-antagonist (partial agonist)
Adverse Effects: Dizziness, depression, insomnia, HYPOTENSION
Contraindications: SINUS BRADYCARDIA, 2/3 DEGREE HEART BLOCK, CARDIOGENIC SHOCK, severe heart failure
Misc: Less bradycardia and lipid abnormalities, less severe side effects

20
Q

Phenoxybenzamine

A

Indication: Pheochromocytoma
MoA: a-blocker
Adverse Effects: PROLONGED HYPOTENSION, REFLEX TACHYCARDIA, nasal congestion
Contraindications: CAD
Misc: Irreversible, decreased BP, increased chronotropy/inotropy

21
Q

Phentolamine

A

Indication: Test for pheochromocytoma, RX FOR PHEO BEFORE SURGERY, catecholamine extravastation
MoA: a-blocker
Adverse Effects: PROLONGED HYPOTENSION, REFLEX TACHYCARDIA, nasal congestion
Contraindications: CAD
Misc: Reversible, decreased BP, increased chronotropy/inotropy

22
Q

Prazosin

A

Indication: Hypertension
MoA: a1-blocker
Adverse Effects: Syncope, ORTHOSTATIC HYPERTENSION
Contraindications: Elderly patients
Misc: Inhibits vascoconstriction, prostate smooth muscle relaxation

23
Q

Doxazosin and terazosin

A

Indication: Prostatic hyperplasia, HYPERTENSION
MoA: a1-blocker
Adverse Effects: Syncope, ORTHOSTATIC HYPERTENSION
Contraindications: Elderly patients
Misc: Inhibits vascoconstriction, prostate smooth muscle relaxation

DRUG BRUTE FORCE MEMORIZATION (7 decks)

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