Adrenal Medulla Fxn Flashcards by Nathan Hansen | Brainscape

Q

Medullary chromaffin cells origin

Medulla is a modified

innervated by

cell bodies located in

axons terminate in

high cortisol inhibits

A

NCC that migrate to center of fetal adrenal gland

sympathetic ganglion

cholinergic pregang symp neurons

spinal cord

medulla

formation of neural processes

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Q

Inc sympathetic activity and medulla

release of

activates

release _____ for secretion

A

Ach

N1 receptors

Epi/Norepi

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Q

Adrenal medullary hormones

____ derived

rate limiting enzyme

Epinephrine synth depends on

stimulated by ____ from the _____

A

Tyrosine

Tyrosine Hydroxylase

PNMT activity

high levels of cortisol in zona fasciculata

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Q

NE and Epi

stored in

these are only

____philic, circulate ____, bind to

Metabolites include

A

chromaffin granules

secreted

hydrophilic, free, GPCR

VMA, Metanephrine, normetaneophrine

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Q

Control of AM hormone sec

_____ output

Inc stress leads to activation of

results in ____ sec/synth

Major hormone released is

less ____, mostly from output of symp nerves

A

Autonomic sympathetic

sympatho-adreno-medullary system (SAM)

inc EPI/NE

EPI

NE

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Q

EPI and NE can act on

AM output is coordinated w

some stimuli evoke a

overs a greater

A

numerous targets to respond to stress

symp nerve response

greater AM response

symp nerve response

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Q

NE and EPI act via

these are ____, response depends on

A receptors for

B receptors for

A

adrenergic receptors

widespread, subtype, density, downstream signnalling

smooth muscle constrict

dilation of SM, cardiac/metabolic effects

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Q

Fight or flight response

Inc CO via

Skeletal muscle arteriolar, via

B, via

Dec ____ and ____ SM activity, via

Inc ____, g____, _____, ____ via

Inc ______ via

Inc _____ via

Inc ______ via

Dec _____ via

A

Beta receptor

VD, BR

bronchodilation, BR

GI/Renal, BR

glycogenolysis, gluconeogenesis, ketogenesis, lipolysis, BR

glucagon sec (BR)

Venous/lymphatic VC, AR

splanchnic arteriolar VC, AR

insulin sec, AR

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Q

Pheochromocytoma

____ tumor of ______ in the ANS

Sx can be ____ or _____

worsen as

Includes

A

Catecholamine secreting, medulla/chromaffin cells

sporadic/paroxysmal

tumor grows

severe HTN, HA, chest pain, palpitations

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