Adrenal

Question 1

Hydrocortisone
\+4 (short to long acting) and potencies
-route
-uses
-tox (and time course)
-smaller tox

Answer 1

Cortisone 10hrs>prednisone, prenisolone 24 hrs> dexamethasone several days
-dex-has all GC potency
-Preds have most GC potency and some MC
-cortisol-GC and MC potency
(MC for BP, GC for inflammation)

all orally bioavailable

IBD, arthritis, allergic reactions, ADDISONS, CAH

Cushingoid Effects-hyperglycemia (DM), fat redistribtuion, protein catabolism (muscle wasing and straie)===occurs >2 weeks therapy
-delayed linear growth in peds

hirsutism/acne, CNS depression, peptic ulcers, immunosuppresiive, insomnia, hypertesnive (if have MC ability)

Question 2

fludracortisone

-type

Answer 2

ALD agonist and some cortisol agonism

Question 3

Ketoconazole

• type
• +1
• use

Answer 3

inhibitors of adnreal steroid biosyn

Metyrapone

CYP17A1 inhibitor (17aOHase)
trx cushings

anti glucocort/andorgenic

Question 4

Mifeprostone

• type
• use

Answer 4

GC receptor antagnoist

trx cushings-adrenal blockers

Question 5

Cabergoline

• type
• use

Answer 5

D2 receptor agonist

trx cushings-ACTH antagnoists

Question 6

Pasireotide

• type
• use

Answer 6

Somatostatin Receptor Agonist

trx cushings-ACTH antagnoists

Question 7

Spironolactone
-type
\+1
-use
-side fx

Answer 7

Mineralocorticoid receptor antagnoist

Eplerenone

Primary ALDsteronism (or Conn’s)

Spirono-can antagnoize androgen and P4 receptors->gyencomastia,m decreased libido, impotence, menstural irregs
-Eplerone is sspecific for MC-no sex hormone side fx

Question 8

Phenoxybenzaime
-type
+3 (but common root)
-use

Answer 8

• alpha blockers
• zosins
• pheo surg prophylactic

Question 9

atenolol
-type
+2
-use

Answer 9

beta blockers

metoprolol and propranolol

-pheo surg prophylactic (after alpha antagonists)

Question 10

Meyrtosine

• type
• use

Answer 10

inhibitors of catecholamine biosyn

pheochormocytoma