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Neuro > ADR > Flashcards

ADR Flashcards

1
Q

Dose-related ADR for ASMs

A

CNS:
- Somnolence
- Fatigue
- Dizziness
- Visual disturbance (blurred, double vision)
- Nystagmus
- Ataxia

GI:
- N&V (carbamazepine, valproate)

Psychiatric:
- Behavioural disturbance (levetiracetam)

Cognition:
- Altered speech fluency (topiramate)

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2
Q

Idiosyncratic ADR for ASM

A
  • Most associated with 1st gen ASM
  • Blood dyscrasia
  • Hepatotoxicity (phenytoin, valproate, carbamazepine)
  • Pancreatitis (valproate)
  • Lupus like reaction
  • Exfoliative dermatitis
  • SJS/TEN
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3
Q

ADR of phenytoin

A
  • Dose-dependent ADR (CNS, GI)
  • Headache
  • Blood dyscrasias
  • Hepatotoxicity
  • SJS/TEN
  • Folate-deficiency, microcytic anemia, peripheral neuropathy
  • Osteomalacia
  • Gingival hyperplasia
  • Hirsutism
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4
Q

ADR of valproate

A
  • Ataxia
  • Tremors
  • Nausea, vomiting
  • Thrombocytopenia
  • Hepatotixicity
  • Pancreatitis
  • Alopecia
  • Weight gain
  • Hyperammonemia
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5
Q

ADR of levetiracetam

A
  • Somnolence
  • Dizziness
  • Headache
  • Asthenia
  • Ataxia (usually within first 4 months)
  • Dyskinesia
  • Irritability, aggression
  • Agranulocytosis
  • Cough
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6
Q

ADR of topiramate

A
  • Somnolence
  • Fatigue
  • Cognition impairment
  • Neutropenia
  • Hepatic failure
  • Depression, mania
  • Glaucoma, temporary vision loss
  • Hyperammonemia, metabolic acidosis
  • Hyperthermia
  • Parasthesia
  • Kidney stones
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7
Q

ADR of carbamazepine

A
  • Dose-dependent ADR (CNS, GI)
  • Headache
  • Blood dyscrasia
  • Hepatotoxicity
  • SJS/TEN
  • Folate-deficiency, peripheral neuropathy
  • Osteomalacia
  • Hyponatremia
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8
Q

ADR of phenobarbital

A
  • Sedation
  • Ataxia
  • Dysarthria
  • Nystagmus
  • Tolerance & dependence
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9
Q

Chronic ADR of ASMs

A
  • Alopecia (valproate)
  • Gingival hyperplasia (phenytoin)
  • Hirsutism (phenytoin), acne
  • Folate deficiency, peripheral neuropathy (phenytoin, carbamazepine, phenobarbital)
  • Weight gain (valproate)
  • Weight loss (topiramate)
  • Osteomalacia (phenytoin, carbamazepine, phenobarbital)
  • Suicidality (carbamazepine, valproate, gabapentin, lamotrigine, levetiracetam, oxcarbazepine, pregabalin, topiramate)
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10
Q

ADR of lamotrigine

A
  • Dizziness
  • Headache
  • Ataxia
  • Dyskinesia
  • Irritability, aggression
  • Hallucination
  • Agranulocytosis
  • Hepatic failure
  • SJS/TEN, DRESS
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11
Q

ADR of pregabalin / gabapentin

A
  • Dizziness
  • Ataxia
  • Weight gain
  • Peripheral edema
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12
Q

ADR of benzodiazepines

A

Standard:
- Drowsiness, confusion
- Amnesia
- Impaired muscle coordination

Overdose:
- Respiratory depression (esp with alcohol)

Withdrawal:
- Disturbed sleep
- Rebound anxiety
- Tremors, convulsion

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Neuro (5 decks)

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