Adolescents Review - Leik Flashcards
Acetaminophen Poisoning (Intentional Ingestion)
Acetaminophen damages the liver, resulting in mild to severe fulminant liver failure.
Acetaminophen also known as paracetamol and sold as Tylenol and others.
Acetaminophen Poisoning (Intentional Ingestion)
Stage 1 (up to 24 hours after overdose): Patients are usually asymptomatic but may have nausea and vomiting and, with very large doses, lethargy, and malaise.
Stage II (24–72 hours after overdose): Patients complain of right upper quadrant pain and have high LFTs, PT, and INR, with possible nephrotoxicity (elevated BUN, creatinine) and/or pancreatitis (serum amylase and lipase elevated).
Most deaths from liver failure occur within 72 to 96 hours.
Treatment acetaminophen poisoning
With acute overdose, serum acetaminophen concentration should be measured as soon as
possible but at least 4 hours must have passed since ingestion to obtain accurate blood level
(if less than 4 hours, blood level is not accurate).
Antidote is N-acetylcysteine given intravenously.
Testicular Torsion (Acute Scrotum)
Pubertal male awakens with abrupt onset of unilateral testicular pain that increases in severity. Pain may radiate to the lower abdomen and/or groin. Almost all patients (90%) also have nausea and vomiting. Ischemic changes result in severe scrotal edema, redness, induration, and testicular pain. Ipsilateral (same-side) cremasteric reflex is absent.
Highest incidence is during puberty. UA is negative for WBCs. Doppler ultrasound is the initial diagnostic test.
Testicle is not functional after 24 hours if not repaired. Refer to ED. This is a surgical emergency.
Testicular Cancer
Teenage to adult male complains of a testicular or scrotal mass that may be tender to touch
or asymptomatic. Some patients may have testicular discomfort, but not pain. The patient
reports a sensation of heaviness in the affected testicle. The affected testicle has a firm
texture. More common in males from the age of 15 to 35 years. Cryptorchidism is a strong
risk factor.
Adolescence
Defined as the onset of puberty until sexual maturity
Adolescence - most common cause of death
Accidents (i.e., motor vehicle crashes)
Puberty
The period in life when secondary sexual characteristics start to develop because of
hormonal stimulation.
Girls’ ovaries start producing estrogen and progesterone.
Boys’ testes start producing testosterone. All of these changes result in reproductive capability.
Girls
Precocious puberty if puberty starts before age 8 years
Delayed puberty if no breast development (Tanner stage II) by age 12 years
Growth Spurt
Majority of somatic changes occur between the ages of 10 and 13 years.
Majority of skeletal growth occurs before menses. Afterward, growth slows down.
Girls start their growth spurts 1 year earlier than boys.
Growth Timeline
Breast development → peak growth acceleration → menarche.
Most of a girl’s height is gained before menarche.
Skeletal growth in girls is considered complete within 2 years after menarche.
Mittelschmerz
Unilateral midcycle pelvic pain that is caused by an enlarged ovarian follicle (or ruptured follicle). Pain may last a few hours to a few days. May occur intermittently.
Menarche
Average age is about 12 years (12.34 years) in the United States (range age 8–15 years)
The first few months after the onset of menarche, it is common to have irregular periods because of irregular ovulation (may skip a month or longer intervals, lighter
bleeding)
After Tanner stage II starts (breast bud stage), girls start menses within 1 to 2 years
Delayed puberty if no secondary sexual characteristics appear by age 12 to 13 years
Menstrual Cycle
Average duration is 28 days; in younger teens, cycles range from 21 to 45 days; in adults, they can range from 21 to 35 days
Average duration of menstrual bleeding is about 3 to 5 days (range 2–7 days)
Day 1 of the menstrual cycle starts as spotting, then blood flow becomes heavier for 2 to 3 days, and then bleeding lightens until it stops
The most fertile period in the cycle is about 3 days before and during ovulation (days 11–14)
Dysmenorrhea
Painful periods due to severe menstrual cramps caused by high levels of prostaglandins
Treatment is use of heating pads and nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Advil, Motrin) and naproxen (Aleve)
Boys
Precocious puberty if starts before age 9 years
Delayed puberty if no testicular/scrotal growth by age 14 years
Growth Spurt
Boys’ growth spurts are 1 year later than girls’ (ages 11–15 years)
Spermarche
Average age is 13.3 years
Tanner Stages - Boys
Stage I: Prepuberty
Stage II: Testes begin to enlarge, with increased rugation of scrotum
Stage III: Penis elongates; testicular/scrotal growth continues; scrotal color starts to darken.
Stage IV: Penis thickens and increases in size; testes are larger and scrotal skin darker
Stage V: Adult pattern
Tanner Stages - Girls
Stage I: Prepuberty
Stage II: Breast bud (onset of thelarche, or breast development)
Stage III: Breast tissue and areola are in one mound
Stage IV: Areola/nipples separate and form a secondary mound
Stage V: Adult pattern
Pubic Hair (Both Genders)
Stage I: Prepuberty
Stage II: Sparse growth of straight hair that is easily counted
Stage III: Hair is darker and starts to curl
Stage IV: Hair is curly but not on medial thigh yet as in adult; hair is coarser
Stage V: Adult pattern; hair spreads to medial thigh and lower abdomen
Immunization Schedule for Adolescents 7-18 years
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Tdap (Boostrix, Adacel)
All 11- or 12-year-olds: Give Tdap as booster, then Td every 10 years for lifetime.
HPV (Gardasil)
All 11- or 12-year-olds: Give to girls and boys. Minimum age (HPV vaccines): 9 years old
All 11- or 12-year-olds: Give first shot. Needs two doses, from 6 to 12 months apart.
From age 15 to 26 years needs three doses.
Meningococcal (ACWY-D [Menactra],
MenACWY-CRM [Menveo], MenB-4C
[Bexsero], MenB-FHbp [Trumenba])
All at age 11–12 years, give single dose of Menactra or Menveo vaccine at age 11–12 years with booster at age 16 years.
Catch-up:
age 13–18 years, give Menactra or Menveo. If first dose at age
13–15 years, needs booster at age 16–18 years.
But if first dose at age 16 years, no booster dose is needed.
Clinical discretion:
Young adults 16–23 years may be vaccinated with either Bexsero or Trumenba.*
Influenza inactivated
Vaccinate everyone from age 6 months and older.