Adnexal masses Flashcards
What is the differential diagnosis of gyn-related adnexal masses?
BENIGN
Functional cyst
Endometrioma
TOA
Mature teratoma
Serous cystadenoma
Mucinous cystadenoma
Hydrosalpinx
Paratubal cyst
Fibroids
Ectopic pregnancy
Mullerian anomalies
MALIGNANT
Epithelial carcinoma
Germ cell tumor
Metastatic cancer
Sex cord or stromal tumor
What is differential diagnosis of non-gyn adnexal masses?
Benign: diverticular abscess, appendicel abscess, ureteral diverticulum, pelvic kidney, bladder diverticulum
Malignant: GI cancers, metastatic cancers
What are personal risk factors for malignancy for adnexal masses?
Age=most important
Personal RF=strong fam hx or breast or ovarian cancer
Nulliparity, early menarche, late menopause, white race, primary infertility, endometriosis.
What decreases the risk of ovarian cancer?
> 5 yr use of OCP
pregnancy <25
lactation
tubal ligation
risk-reducing BSO
removal of fimbrial ends
What is the differential diagnosis of bilateral adnexal masses?
germ cell tumors (5-10%)
fibromas (10%)
serous carcinoma (66%)
mucinous carcinoma (20%)
krukenberg (100%)
endometriomas
theca lutein cysts
TOA
How do you assess the risk of ovarian cancer?
- Multivariate index assay (qualitative serum tumor marker panel)- incorporates 5 serum biomarkers into score (CA-125, transferrin, prealbumin, apolipoprotein a1, b2 macroglobulin)
- ROMA: Risk of ovarian malignancy algorithm
- Ca-125, human epidiymal protein 4, menopausal status). Multimodal tests are algorithms that incorporate serum markers, clinical information and US findings.
At what age do you perform an elective oophorectomy at the time of hysterectomy?
Traditionally was age 65. Updated Markov model says age 50 and older. Initiating estrogen in those who needs BSO before age 50, adding estrogen. Hysterectomy and BSO after age 50 confers the same survival to age 80 years as performing hyst alone before age 50.
What are causes of elevated Ca-125?
What values are abnormal for pre and post-menopausal women?
Epithelial ovarian cancer
Endometriosis
Pregnancy
PID
Non-gyn cancer (Breast, lung, pancreatic cancers)
Values considered abnormal: post-menopausal>35 and pre-menopausal>200
What are types of ovarian cancer?
Type 1 Epithelial cancer: Serous (CA-125), Mucinous adenocarcinoma (CEA), Endometrioid (Ca-125), Clear cell (Ca 125), Brenners
Type 2 epithelial cancer: high-grade serous, undifferentiated carcinoma, carcinoma (most originate in fallopian tube epithelium)
Sex-cord stromal: granulosa cell (Estrogen), fibroma, thecoma, lipid cell, sertoli leydig (testosterone), gynaddroblastoma
Germ cell: mature teratoma, immature teratoma (AFP, CA-125), dysgermimoma (LDH), gonadoblastoma, embryonal carcinoma (AFP, HCG), endodermal sinus (AFP)
Mixed-cell type
US findings suggestive of malignancy?
- Cyst size >10
- thick separations (>2-3mm) or complex architecture
- irregular wall or nodularity
- bilateral cysts
- high color flow on doppler assessment
- solid and cystic compomenents
- presences of ascites on US
Who should you refer to gyn onc?
1 or more of following criteria:
- postmenopausal with elevated Ca-125, US findings suggestive of malignancy, ascites, nodular/fixed pelvic mass, evidence of abdominal/distant mets.
- Premenopausal w/ very elevated Ca-125, US findings suggestive of malignancy
Pre or postmenopausal w/ elevated score on formal risk assessment test.
What are considerations for evaluation/management of adnexal masses in adolescents?
What tumor markers should you order?
Prioritize ovarian conservation to preserve fertility. Usually benign, often expectant management. Do menstrual history, question sexual activity, transabdominal US. can odo simple cystectomy. Elevation in Ca-125 can occur w/ ovarian malignancies but also w/ non-communicating uterine horns, ovarian fibromas, or torsed adnexa.
physical exam: palpate mass: smooth, nodular, tender, mobile etc.
- AFP (endodermal sinus)
- b-hcg (pregnancy)
- LDH (dysgermimoma) are indicated for evaluation of suspected germ cell tumors.
What to do if malignancy is identified at time of surgery?
Remove tumor without spilling contents, sparing fallopian tube if not adherent, harvest ascites for cytology, examine/palpate omentum w/ biopsy or remove suspicious areas, examine iliac vessels.
When is aspiration of adnexal mass appropriate?
If TOA (failed antibiotic therapy)
- benign simple cysts (recurrence rate 44% for pre-menopausal, less for post-menopausal)
- suspected advanced cancer for which neoadjuvant therapy is planned. Otherwise contraindicated if suspicion for cancer!
What is the recommended management for mature teratomas and endometriomas?
When would you do surgery?
Surgery if large, symptomatic, or growing on imaging. Expectant management an option. Surgical excision of endometriomas can adversely affect ovarian reserve so asymptomatic ones DO NOT require intervention for infertility. If pt requires surgery, conserve as much ovarian tissue as possible.