Adipose Tissue Flashcards
What chemicals does adipose release?
Leptin CRP TNF alpha IL-6 Oestrogen Cortisol Free fatty acids
What is the function of leptin in the body?
Tracks and monitors bodies adipose levels
If there are low levels of leptin what does this trigger?
Increased appetite
Decreased thermogenesis
If there are high levels of leptin what does this trigger?
Decreased appetite
Increased thermogenesis
What is the only drug licensed for weight loss?
Orlistat
What is the mode of action of orlistat?
Lipase inhibitor
Blocks dietary absorption of fat
What are some side affects of Orlistat?
GI diarrhoea
Steatorrhea
What are the three forms of bariatric surgery
Adjustable gastric band
Roux-en-Y gastric bypass
Vertical sleeve gastrectomy
What are the pros and cons of a gastric band?
Least invasive
However if there is dramatic weight loss the band can slip superiorly and inhibit any food intake
At what weight can you be considered for bariatric surgery?
BMI 40
BMI 35 with significant related health issues e.g. diabetes