ADHD and Autism Treatment

Question 1

Stimulants (schedule II controlled substance)

Answer 1

First line therapy
Methylphenidate (Ritalin)
Amphetamines
Detroamphetamine (Adderall)
Detroamphetamine-amphetamine

Question 2

Atomoxetine

Answer 2

2nd line therapy

Atomoxetine (Strattera) is an alternative (non stimulant)

Question 3

Short acting stimulants: Methylphenidate

Answer 3

Ritalin and Methylin are the short acting formulations
Time to onset of action ranges from 20 to 60 minutes.
Duration of action is three to five hours and the half-life is two to three hours.

Question 4

Long acting stimulants: Methylphenidate

Answer 4

:Onset of action 20-60min, duration of action 8 hrs
Single pulse: Metadate ER, Methylin ER and Ritalin SR

12 hours:
Osmotic release:  Concerta
Oral suspension:  Quillivan XR
Transdermal:  Daytrana: Effects last 3 hours post removal of the patch
Onest

Question 5

Short acting stimulants: Amphetamines

Answer 5

Detroamphetamine
Dexedrine, Dextrostat, Procentra (Oral soln)
Onset of action 20 min, duration of action 4-6 hrs

Amphetamine-dextroamphetamine
Adderall
Onset of action 20 min, duration of action 4-6 hrs

Question 6

Long acting stimulants: Amphetamines

Answer 6

Lisdexamfetamine (Vyvanase): 10-12 hours
Dextroamphetamine SR (Dexedrine spansule)
Amphetamine-dextroamphetamine (Adderall XR): 6-8 hours
Onset of action 20 min, duration of action 8-10 hrs

Question 7

stimulant adverse effects

Answer 7

Decreased appetite
Poor growth
Dizziness
Insomnia/Nightmares
Mood lability
Rebound
Tics
Psychosis
Diversion and misuse

Question 8

Ritalin (Methylphenidate)

Answer 8

Short and long acting methylphenidate available
Acts on dopamine and norepinephrine to block reuptake
High potential for addiction and abuse
Schedule II drug

Question 9

Amphetamine-dextroamphetamine (Adderall)

Answer 9

high potential for abuse
May lead to drug dependence
Extremely popular
May be slightly more effective than Ritalin
Also schedule II
Anxiety
Weight loss
Psychiatric issues like psychosis
Heart problems in at risk people (sudden death)

Question 10

Detroamphetamine (Dexedrine)

Answer 10

Previously used for otc diet pill
Marketed very well
Among most effective treatment for ADHD
Schedule II
Sudden death in people that have heart probs or defects