ADHD Flashcards

1
Q

When did Attention Deficit Disorder first appear?

A

DSM III

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What did Alexander Crichton observe and when?

A

A disease of attention, in 1798, “they say they have the fidgets,” boys more than girls, attention difficulties emerged in early life, believed symptoms were exacerbated by the rigid British educational system and advocated for customizing education environments to capitalize on individual strengths and improve learning

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Selective attention

A

The ability to concentrate on relevant stimuli and not be distracted by noice or other elements of the external environment

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Sustained attention

A

The ability to concentrate and maintain persistent focus over time or when fatigued

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

How do we classify ADHD?

A

A neurodevelopmental disorder

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What is a neurodevelopmental disorder?

A

Something people are born with and which changes as they change throughout their lives, long term, evident from very early in life

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What are the 3 subtypes of ADHD?

A
  • Predominantly inattentive
  • Predominantly hyperactive-impulsive
  • Combined
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

ADHD Diagnostic Criteria intro

A

A persistent pattern of inattention and/or hyperactivity-impulsivity that interferes with functioning or development, as characterized by either A or B

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

ADHD Criteria A

A

Inattention:
Six or more (5 for age 17+) of the following symptoms have persisted for at least 6 months to a degree that is inconsistent with developmental level and that negatively impacts directly on social and academic/occupational activities:
- Often fails to give close attention to details or makes careless mistakes in school work, at work, or during other activities
- Often has difficulty sustaining attention in tasks or play activities
- Often does not seem to listen when spoken to directly
- Often does not follow through on instructions and fails to finish schoolwork, chores, or duties in the workplace
- Often has difficulty organizing tasks and activities
- Often avoids, dislikes, or is reluctant to engage in tasks that require sustained mental effort
- Often loses things necessary for tasks or activities
- Is often easily distracted by extraneous stimuli
- Is often forgetful in daily activities

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

ADHD Criteria B

A

Hyperactivity or impulsivity:
Six or more (5 for age 17+) of the following symptoms have persisted for at least 6 months to a degree that is inconsistent with developmental level and that negatively impacts directly on social and academic/occupational activities:
- Often fidgets with or taps hands or feet or squirms in seat (psychomotor agitation)
- Often leaves seat in situations when remaining seated is expected
- Often runs about or climbs in situations where it is inappropriate (feeling restless in adults)
- Often unable to play or engage in leisure activities quietly
- Is often on the go, acting as if driven by a motor
- Often talks excessively (hyperverbal)
- Often blurts out an answer before a question has been completed
- Often has difficulty waiting their turn
- Often interrupts or intrudes on others

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

ADHD other criteria

A

Several symptoms (doesn’t have to be all) present before age 12
Several symptoms present in two or more settings
Clear evidence symptoms interfere with quality of functioning- poses some degree of problem
Not during schizophrenia or better explained by another mental disorder- decline in attention is part of a lot of disorders, ie mood disorders

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

ADHD C

A

Meet full diagnostic criteria for A and B- 12 symptoms total

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Which ADHD type is most often referred for treatment?

A

Combined, probably because cumulative impact of 12 symptoms (least common though and seems least malleable)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Prevalence of ADHD

A

2-4% girls, 6-8% of girls

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Gender differences in ADHD in childhood

A

Girls may be more likely to display inattentive and disorganized symptoms, less disruptive than hyperactive (most referrals by schools not parents)
Girls with HI are referred at a younger age (bc social expectations for girls), hyperverbal (interrupting, talking a lot) rather than hyperactive
*We often miss diagnoses girls, girls more likely to be inattentive, bc ADHD diagnosis developed based on young boys and adapted for girls

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

ADHD comorbidity (not anxiety)

A

Many kids w ADHD meet criteria for other disorders too, highly comorbid- diagnostic difficulty, what is a difficulty w attention due to ADHD or something else
Earlier onset of ADHD associated with elevated risk for comorbid externalizing- CD and ODD, ADHD tends to precede these (not majority w ADHD go on to ODD but yes a majority of ODD have attentional symptoms before ODD diagnosis)
Comorbidity with externalizing is more common among ADHD-HI subtype

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

ADHD comborbidity w anxiety

A

Internalizing disorders are more likely to be comorbid w inattentive subtype, high comorbidity particularly w anxiety disorders
Compared w children w anxiety disorders and NOT ADHD, kids w ADHD and anxiety are less likely to have fears of concrete things and more likely to express anxiety related to ADHD- worries about competency, what other people think of them, school performance
Internalizing disorders tend to emerge after onset of ADHD, maybe explained by lived experience and ADHD related stress

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Basal ganglia

A

Group of structures that work together, important for response control and inhibition and impulsivity, lesions here result in symptoms look like ADHD

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Striatum

A

Part of BG

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Frontostriatal circuitry

A

Neural pathways between striatum and frontal lobe, messages passed through this neural network

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Frontostriatal circuitry in ADHD

A

Diff in structure and function, messages passed less quickly and efficiently, frontal lobes smaller in volume, striatum is different shape than people w/o ADHD

22
Q

Caudate

A

Part of striatum

23
Q

Caudate in ADHD

A

Should look like a comma- left head bigger than right, in ADHD it is smaller instead of larger

24
Q

Neural maturation and ADHD

A

ADHD associated with slower pace of neural maturation
During childhood, cerebral cortex thickens as children build thousands of new synapses in the brain, then eliminate ones it doesn’t need
In ADHD, peak cortical thickness- 10.5 years, in w/o- 7.5 years

25
Q

Gyrification

A

Process of forming the crinkly folds of the cerebral cortex, creates a greater surface area for brain

26
Q

Gyrification and ADHD

A

Kids w ADHD take longer to develop peak surface area in process of forming cortical folds, ab 2 years longer
Eventually, catch up but seems people w ADHD have brains that look younger during parts of childhood and adolescence

27
Q

Genetics of ADHD

A

One of most heritable disorders, h^2 = 0.7
Rates of ADHD 3x higher in biological parents of kids w ADHD than adoptive parents
Dopaminergic genes- important for secretion of dopamine, meds that work for ADHD work on dopamine neurotransmission- worked backwards, impulsivity regulated by dopamine genes?

28
Q

Identical twins w ADHD

A

Mostly either both have or don’t, in cases in which one has ADHD, only twin w ADHD shows alteration in frontostriatal circuitry, evidence that this causes ADHD

29
Q

Lead and ADHD

A

More lead in blood, more ADHD symptoms
Kids w ADHD have blood lead levels 20-30% higher than kids w/o ADHD
Diathesis stress hypothesis that environmental exposure to lead activates an underlying genetic predisposition to ADHD
Even a little lead shows declines in cognitive control
CDC warning level is twice as high as causes issue in adults
Lead attaches itself to receptor sites (binds to neurons) in frontal cortex and striatum and disrupts brain development/brain activity/both

30
Q

Where are kids exposed to lead?

A

Toys- pigments in plastics, esp softer plastics, kids learn about world by putting stuff in mouths

31
Q

Lead and income

A

Exposure to lead correlates highly with SES, lead paint more common in older housing, some lead exposure is unavoidable but efforts to avoid it are expensive and inaccessible

32
Q

ADHD treatment

A

Grown a ton, mostly psychopharmacology, more effective than behavioral techniques though some do exist- parent management training programs for ADHD-HI to manage HI behavior at home, educational interventions involving teachers

33
Q

ADHD medications

A

Very effective, 80% kids show dramatic improvement in attention, mostly psychostimulants, safe for long term use

34
Q

How do psychostimulants work?

A

Increasing dopamine levels in frontalstriatal circuitry, show decreases in hyperactivity, sustained attention improving, persistence of work effort improves, test better on tests of attention/problem solving/speeded tasks

35
Q

Developmental sensitivity of symptoms

A

Identical symptom may mean different things at different points during the lifespan
Behaviors or situations which are normative at one age might be aberrant at others, so it is important to consider normative development and context in evaluating symptoms

36
Q

Pitfalls of ADHD diagnosis

A

ADHD diagnosis requires emergence of symptoms before age 12, rise in interest and questions about adult ADHD

37
Q

DSM diagnosis history

A

Originally, criteria were not developmentally sensitive
Developed exclusively based on studies of children (mostly white boys) and intended to be broadly applied by not reflective of ADHD in adulthood

38
Q

ADHD longitudinally

A

Some early studies showed that ADHD might go away in adulthood bc adults didn’t clearly fit diagnosis criteria
Now show most people w ADHD in childhood report difficulties with organization and concentration as adults, not a spontaneous remission, most clearly still meet DSM criteria but not always

39
Q

Adult ADHD phenotype

A

We’re still mapping it

40
Q

Why is it hard to understand what ADHD in adulthood looks like?

A
  1. ADHD symptoms change over the lifespan, inattentive symptoms persist while hyperactive symptoms decrease- kinda. Does the symptom decrease indicate true symptom remission or problems with the sensitivity of the diagnostic criteria? Do we have a good sense of what HI looks like in an adult?
  2. Comorbidity- adult ADHD highly comorbid with other disorders, 75% of ppl w adult ADHD have been diagnosed w at least one other disorder, most also involve difficulty w concentration and focus and organization and psychomotor agitation, so what is attributable to ongoing ADHD and what is bc of other disorder
  3. Nonspecific effects- can’t rely on treatment response to indicate disorder, psychostimulants have nonspecific effects: effective at improving target symptoms even if people don’t have the disorder they are intended to treat, these improve focus and concentration for everyone, efficacy is not proof of diagnosis
  4. We haven’t adequately studied sex, gender, and ADHD
41
Q

Sex, gender, ADHD

A

Significant differences in prevalence in ADHD- 3x more common in males
Og DSM research was boy focused

42
Q

Gender and ADHD in adulthood- Hinshaw

A

Inconsistencies in research lit
Disparity in prevalence across males and females is narrower in adulthood than childhood- we shouldn’t see this, some kind of issue, neurodevelopmental disorders stay through lifespan, should see consistency
Are there true differences in prevalence and course by gender?
- Bc HI go down but PI persists, maybe some true discrepancies in symptoms across gender and age
Are there gender discrepancies in identification and referral?
- Maybe over-ref of boys and under of girls
Are there biases with diagnostic criteria?
- Skew more towards boys’ experiences

43
Q

Maria Yagoda

A

Diagnosed in college, had internalized symptoms as personal failings
Loses things, hard time adhering to work schedule, chaotic room, difficulty keeping up with basic life tasks

44
Q

ADHD diagnosis issues

A

Most ADHD diagnoses hold up to scrutiny across lifespan by multiple professionals, missed diagnosis is more common than a misdiagnosis

45
Q

When is misdiagnosis most common in ADHD?

A

When normal attentional changes in age are diagnosed as ADHD

46
Q

School cutoff research design in ADHD

A

School systems vary in cutoff date for eligibility to enroll in kindergarten- kids who are 11 months apart in one classroom, compare kids across school systems to understand how much schooling matters for the development of different processes, used to study how much age matters for diagnosis of ADHD
Quasi-experimental, not manipulating but can infer causality of being younger/older for grade on ADHD diagnosis prevalence

47
Q

School cutoff research ADHD results

A

In schools w Sept 1 cutoff, highest ADHD diagnosis and medication in August (youngest in class) and plummets in September (oldest in class), same thing with Dec 1 cutoff between November and December
Kids who are young for grade are more likely to be diagnosed w ADHD regardless of when cutoff is, international phenomenon but generally more common in countries where ADHD meds prescribed more frequently, conflating normative developmental differences in attention with possibility of ADHD

48
Q

Why is this school cutoff stuff shown?

A

Teachers play a vital role in referring children for ADHD diagnosis, younger kids have reduced attention spans and more impulsivity, draw teacher’s attention more, so it is important to consider normal development as a foundation for understanding psychopathology

49
Q

How to confirm ADHD diagnosis

A

ADHD involves cognitive impairment, evident when we ask people to do a variety of different cognitive tasks- neuropsychological testing, given other cognitive capacities, do we see what we expect in attention or no, test battery should include attentional and nonattentional tasks and extensive clinical interview, not bulletproof in terms of ADHD v other cognitive impairments but can differentiate ADHD w other psychiatric diagnoses that mimic ADHD symptoms and malingering (feigning symptoms), important to test people while not on psychostimulants, can help correct gender disparity

50
Q

Examples of ADHD tests

A

Digit span- starts easy, progresses to harder, ends when people miss a bunch in a row, at first just in order and then go backwards, measure of basic auditory attention and working memory, average 7 forward 5 backward, interested in difference
Trail Making Test (A and B)- excellent measure of exec functioning, timed task and tends to be slower in ADHD, A- move between circles 1-2-etc interested in time and how many errors, B- same but alternate numbers and letters, 1-A-2-B etc, interested in what happens with increasing task complexity- difference between A and B
Stroop Task- say color of word but word is different color name (come back to slide)

51
Q
A
52
Q
A