ADHD Flashcards
Which drugs are recommended as first-line treatment for ADHD?
Lisdexamfetamine mesilate
or
Methylphenidate hydrochloride
Start on either, after 6 weeks, switch to the other if there is no improvement of symptoms
What drug can be given if a patient is benefitting from lisdexamphetamine but cannot tolerate its longer duration of effect?
Dexamfetamine sulfate
What drug can be given when a patient with ADHD is intolerant to both Methylphenidate hydrochloride and Lisdexamfetamine mesilate?
Atomoxetine?
- non stimulant
What are the contraindications of Lisdexamfetamine mesilate?
- Advanced arteriosclerosis
- Agitated states
- Hyperthyroidism
- Moderate hypertension
- Severe Hypertension
- Symptomatic cardiovascular disease
What are the cautions of Lisdexamfetamine mesilate?
- Bipolar disorder
- Hx of cardiovascular disease
- Hx of substance abuse
- May lower seizure threshold
- Psychotic disorders
- Susceptibility to angle-closure glaucoma
- Tics
- Tourette syndrome
What are the common side effects of Lisdexamfetamine mesilate?
- Anxiety
- Appetite decrease
- Dyspnoea
- Jittery
- Abnormal behaviour
- Hyperhidrosis
- Altered mood
- Sexual dysfunction
- Tachycardia
- Tremor
In severe renal impairment, what is the maximum dose of What are the cautions of Lisdexamfetamine mesilate?
Max dose 50 mg daily
What are the contraindications of Methylphenidate hydrochloride?
Anorexia nervosa
Arrhythmias;
Cardiomyopathy;
Cardiovascular disease; Cerebrovascular disorders; Heart failure; Hyperthyroidism;
Mania;
Phaeochromocytoma; Psychosis;
Severe depression;
Severe hypertension; Structural cardiac abnormalities;
Suicidal tendencies; Uncontrolled bipolar disorder;
Vasculitis
What are the cautions of Methylphenidate hydrochloride?
Agitation Alcohol dependence Anxiety Drug dependence Epilepsy Fhx of Tourettes Susceptibility to angle-closure glaucoma Tics
What are the common side effects of Methylphenidate hydrochloride?
Hostility Alopecia Anxiety Appetite decreased Arrhythmias Arthralgia Change in behaviour Depression Hypertension, Altered mood Sleep disorders Vomiting Decreased weight
What are the contraindications of Atomoxetine?
- Phaeochromocytoma
- Severe cardiovascular disease
- Severe Cerebrovascular disease
What are the cautions of Atomoxetine?
QT-interval prolongation Aggressive behaviour Cardiovascular disease Cerebrovascular disease Hx of seizures Hostility Hypertension Mania Psychosis
