Adenovirus and Gene therapy

Question 1

Adenovirus

Answer 1

Unique = covalently bound protein at 5' end
Spikes bind to receptor
linear
E1A = transcription activator
E1B = modifying genes

Question 2

Adenovirus transmission

Answer 2

binds -> coated vesicle -> endosome (lower pH) -> on microtubule -> nucleopore complex

Question 3

Adenovirus types

Answer 3

Group A: subclinical
B: acute respiratory illness, pneumonia
C: mild upper respiratory illness
D: Conjunctivitis
E: Epidemic severe respiratory disease
F: diarrhea in children