Adenovirus

Question 1

What are adenoviruses?

Answer 1

A group of viruses that cause respiratory, gastrointestinal and genitourinary infections

Question 2

What are the 4 genera of adenovirus?

Answer 2

• Mastadenovirus (Mammals, including humans)
• .Aviadenovirus (Birds)
• Atadenovirus (Birds, mammals, reptiles, marsupial)
• Siadenovirus (Reptiles, birds)

Question 3

What is the classification of adenoviruses?

Answer 3

Baltimore class 1

Question 4

How does adenovirus transmission occur?

Answer 4

It is primarily transmitted through respiratory droplets when one coughs or sneezes or by fecal oral route.
Can also be transmitted from mother to infant via birth canal or following organ transplant from infected donor

Question 5

How many serotypes does adenovirus have?

Answer 5

51

Question 6

What are the treatments for adenovirus?

Answer 6

There are no specific treatments however immunocompromised patients may receive antiviral therapy

Question 7

How does Cidofovir work?

Answer 7

It is a nucleotide analog of cytosine and it inhibits the viral DNA polymerase and viral replication by competitive incorporation of its active metabolite codofovir diphosphate into the viral DNA chain.
This disrupts its synthesis and replication

Question 8

What are the serological investigations done for diagnosis of Adenovirus?

Answer 8

Virus is isolated from clinical samples like faeces, pharyngeal swabs and conjunctival swabs

It can be cultured on human diplo fibroblast. HeLa cervical cancer and Hep-2 epithelial cells

Question 9

What are Rapid identification tests for adenovirus?

Answer 9

Immunofluorescence

Subtyping by hemagglutination inhibition test with antisera

Question 10

What are the 4 groups of viruses?

Answer 10

Adenoviruses
Coronaviruses
Severe Acute respiratory syndrome
Rhinoviruses