Adenoviridae

Question 1

Adenoviridae

Answer 1

Double stranded DNA
Serotypes 40 and 41 cause diarrhoea
Entreric adenoviruses are fastidious

Question 2

Pathogenesis of adenoviruses

Answer 2

Mainly by respiratory or oro-faecal contact from humans
They multiply in the small intestine and then spread to mesentery where epithelial cells are infected
can become latent in lymphoid tissue

Question 3

Immunity to adenoviruses

Answer 3

Characterised by development of effective long lasting immunity to the same serotype

Question 4

Symptoms of adenoviruses

Answer 4

Primarily affects children
Incubation period is from 5-8 days
Ususally occurs in day cares
Manifests as fever and water diarrhea which resolves within one to two weeks

Question 5

Lab diagnosis

Answer 5

Fecal specimen
CPE: cell rounding and aggregation into grape like clusters
Stool electron microscopy
Serology for antibody titre

Question 6

Treatment

Answer 6

no vaccine

Question 7

Adeno-associated viruses

Answer 7

Belong to family parvoviridae (Group B)

Unable to replicate independently as they do not have enough DNA

Question 8

Other uses of adenoviruses

Answer 8

Vaccine carriers