Adenosine (Adenocard)

Question 1

Class

Answer 1

Antidysrhythmic

Question 2

Mechanism of Action

Answer 2

Slows AV node conduction, can interrupt re-entry pathway, decrease HR by acting on sinus pacemaker cells, Drug used for re-entry SVT, diagnostic use for stable wide complex-tachycardia post 2 doses of lidocaine

Question 3

Indications

Answer 3

Conversion of PSVT to sinus rhythm, Wolf-Parkinson White Syndrome, most stable narrow complex SVT, not effective for a fib/flutter conversion

Question 4

Contraindication

Answer 4

2nd or 3rd degree AV block (if no pacemaker), sick-sinus syndrome (if no pacemaker), asthma, COPD, drug induced tachycardia

Question 5

Averse Reactions

Answer 5

HA, dizziness, dyspnea, bronchospasm, dysrhythmias, palpitations, hypotension, cpx, flushing, cardiac arrest, nausea, metallic taste, paresthesia, diaphoresis

Question 6

Drug Interactions

Answer 6

Theophylline-like drugs have antagonistic effects, Dipyridamole potentiates effect, Carbamazepine potentiates AV node blocking effect

Question 7

How Supplied

Answer 7

3mg/ml, in 2ml or 5ml vials

Question 8

Dosage and Administration

Answer 8

Adult: 6mg rapid IVP bolus (1-3 sec), followed by 20ml flush, elevate extremity. May repeat after 1-2 min with 12ml IVP bolus (1-3 sec)
Ped: .01 mg/kg IVP/IOP (max 1st dose 6mg) followed by 5-10 ml flush. May repeat 2nd dose of .2mg/kg IVP/IOP followed by flush

Question 9

Duration of Action

Answer 9

Onset: seconds
Peak: seconds
Duration: 12 sec

Question 10

Special Considerations

Answer 10

Pregnancy: Cat C
Bronchoconstriction in asthma pts, Evaluate elderly pts for dehydration requiring fluid replacement prior to administration