Adenergic receptors Flashcards
1
Q
α1(Target action)
A
- Vascular, genitourinary smooth muscle contraction
- Intestinal smooth muscle relaxation
- Liver: glycogenolysis, gluconeogenesis
- Salivary secretion
2
Q
α2(target action)
A
- Panreas: decrease insulin secretion
- Nerve terminals: Decrease NE release
- CNS: decrease sympathetic tone
- Platelet aggregation
3
Q
β1(Target action)
A
- Heart: Increase force(+ionotropic), Increase rate(+ chronotropic) Increase AV conduction velocity
- Kidney: increase renin release
4
Q
β2(Target action)
A
- Smooth muscle relaxation
- Skeletal muscle glycogenolysis
- Liver: glycogenolysis, Gluconeogenesis
5
Q
D1(Target action)
A
Dilates renal vasculature
6
Q
Direct acting sympathomimetic drugs
A
Clonidine Albuterol Norepinephrine Phenylephrine Isoproterenol Epinephrine
7
Q
Indirect acting sympathomimetic drugs
A
Mao inhibitors Tyramine Ephedrine Amphetamine Cocaine Tricyclic antidepressants
8
Q
Epinephrine(selectivity)
A
α, β nonselective
9
Q
Norepinephrine(selectivity)
A
α, β1 > β2
10
Q
Isoproterenol(selectivity)
A
β
11
Q
Phenylephrine(selectivity)
A
α1
12
Q
Albuterol(selectivity)
A
β2
13
Q
Clonidine(selectivity)
A
α2(centrally active)
14
Q
Therapeutic uses of adrenergic agonists and target
A
- Nasal decongestants(α1)
- Slow absorption of local anesthetics(α1)
- Antihypertensive(α2)
- Treatment of shock(β1, dopamine)
- Cardiopulmonary resuscitation( α1 epi)
- Asthma(β2, airway smooth muscle)
- Anaphylactic reactions(mast cells β2; α1 resistance vessels)
- Mydriasis (radial muscle α1)
- Wide angle glaucoma(α1 for vasoconstriction: α2 for reduced secretion)
- Delay premature labor( uterine β2)
15
Q
Toxicity & side effects of adrenergic agonist
A
- Hypertensive reactions– cerebral hemorrhage( α1)
- Cardiac ventricular arrhythmias
- Myocardial ischemia
- Vasoconstriction, ischemia
- CNS Stimulation-Rebound nasal congestion
- withdrawal syndrome from α2 agonists
