Additional Hemepath

Question 1

what findings on smear are seen with G6PD?

Answer 1

blister cells and bite cells

Question 2

For Chediak Higashi what is the underlying problem and what is seen on smear?

Answer 2

Its a lysosome problem

see large azurophilic or grey granules in the neutrophils and lymphocytes

Question 3

what are howell jolly bodies

Answer 3

Are DNA remnants in the RBC
found in post-splenectomy patients
severe hemolytic anemia
CDA
premature babies

Question 4

what is basophilic stippling?

Answer 4

aggregated ribosomes with incompletely degraded RNA
lead poisoning
Pyrimidine 5' deficiency
thal
hemoglobinopathies
sideroblastic anemia
MDS
CDA

Question 5

What are pappenheimer bodies?

Answer 5

lysosomes containing iron-protein complexes

seen asplenia, iron overload

Question 6

Heinz bodies

Answer 6

aggregates of denatured Hb which is attached to the inner RBC membrane, need supravital stain in order to visualize
seen in G6PD, hereditary Heinz body hemolytic anemia,

Question 7

what is seen in HbH disease on smear?

Answer 7

precipitates of excess beta tetramer chains, but need to use the supravital dye in order to visualize

Question 8

what is the pelger-huet anomaly?

Answer 8

caused by mutations in the lamin B receptor
heterozygotes will have bilobed neutrophils
homozygotes will have round unilobed nuclei

Question 9

what is seen on smear in patients with mucopolysaccharidosis?

Answer 9

WBC can have an increase in azurophilic granules

Question 10

in lysosomal storage diseases (ie mucopolysaccharidoses, galactosialidosis)

Answer 10

associated with vacuolated lymphocytes