Addictions Flashcards
opioid withdrawal brain area
locus coeruleus
opioid withdrawal symptoms
myalgia/arthralgia
hyperalgesia
GI upset
anxiety
moodiness/dysphoria
irritability
insomnia
hot/cold flushes
poor concentration
increased drug craving
opioid withdrawal signs
tachycardia
hypertension
diaphoresis
rhinorrhoea
oscitation (yawning)
increased lacrimation
muscle twitching
restlessness
diarrhoea
piloerection
tremor
mydriasis
what receptors do opioids act on
mu - main!
kappa
delta
first line opioid detox drugs
methadone or buprenorphine
pellagra
vitamin B3 deficiency
4 D’s:
dermatitis
diarrhoea
dementia
death
stimulant withdrawal (amphetamine, cocaine)
dysphoric mood
fatigue
vivid unpleasant dreams
insomnia or hypersomnia
increased appetite
psychomotor retardation or agitation
MDMA withdrawal
depression
insomnia
depersonalisation
derealisation
cannabis withdrawal
irritability
aggression
anxiety
sleep problems
poor appetite
weight loss
restlessness
depressed mood
abdo pain
shakiness/tremor
sweating
fever
chills
headache
which drugs dont have a recognised withdrawal syndrome
hallucinogens (eg LSD)
ketamine
first line NICE recommendations for alcohol detoxification
- acamprosate
- naltrexone
second: disulfiram, nalmefene (but limited evidence)
clozapine hypersalivation receptors
muscarinic and adrenergic
what vitamin is niacin
vitamin b3
Wernicke’s triad…
global confusion
ophthalmoplegia
ataxia
wernicke’s features (7)
ataxia
hypothermia
hypotension
confusion
ophthalmoplegia/nystagmus
memory disturbance
unconsciousness/coma
