Addiction Flashcards
1
Q
define tolerance?
A
reduced responsiveness to a drug causes by previous administration
2
Q
what term for when less drug reaches the active site?
A
dispositional tolerance
3
Q
what term for when drug has less action at the active site?
A
pharmacodynamic tolerance
4
Q
reasons for dispositional tolerance? (3)
A
less drug absorbed
drug metabolised faster
more drug excreted
5
Q
reasons for pharmacodynamic tolerance? (2)
A
fewer drug receptors
less efficient drug receptors
6
Q
what is the withdrawal phenomena?
A
the withdrawal effect is usually the reverse of the acute effect of the drug
7
Q
what do some drugs do to the reward centre?
A
increase dopamine levels
8
Q
two distinct components of dependence?
A
physical dependence
psychological craving
(much more complex in humans)
